Publication Name	World Journal of Gastroenterology
Manuscript ID	7596
Country	Italy

Received	2013-11-26 12:38
Peer-Review Started	2013-11-26 23:05
To Make the First Decision	2014-01-24 10:19
Return for Revision	2014-01-26 16:34
Revised	2014-02-07 19:37
Second Decision	2014-05-14 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-14 09:38
Articles in Press	2014-05-23 09:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-01 09:49
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Nonalcoholic fatty liver disease and the heart in children and adolescents
Manuscript Source	Invited Manuscript
All Author List	Lucia Pacifico, Claudio Chiesa, Caterina Anania, Antonio De Merulis, John Frederick Osborn, Sara Romaggioli and Eugenio Gaudio
Funding Agency and Grant Number
Corresponding Author	Claudio Chiesa, MD, Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere, 100, 00133-Rome, Italy. claudio.chiesa@ift.cnr.it
Key Words	Nonalcoholic fatty liver disease; Children; Atherosclerosis; Cardiac structure; Cardiac function
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is an important and emerging health problem in childhood. It is recognized as part of the metabolic syndrome and especially the necroinflammatory form is associated with a high risk for the development of functional and structural vascular changes as well as left ventricular dysfunction at an early age. In addition, there seems to be a complex bidirectional relationship between the progression to nonalcoholic steatohepatitis (NASH) and the development of insulin resistance and cardiovascular abnormalities. Early intervention during childhood to recognize NAFLD, as well as to prevent its progression to NASH, may be a crucial step in averting an unfavorable cardiac phenotype.
Publish Date	2014-07-21 17:17
Citation	Pacifico L, Chiesa C, Anania C, De Merulis A, Osborn JF, Romaggioli S, Gaudio E. Nonalcoholic fatty liver disease and the heart in children and adolescents. World J Gastroenterol 2014; 20(27): 9055-9071
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/9055.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.9055

Full Article (PDF)	WJG-20-9055.pdf
Full Article (Word)	WJG-20-9055.doc
Manuscript File	7596-Review.docx
Answering Reviewers	7596-Answering reviewers.pdf
Copyright License Agreement	7596-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7596-Language certificate.pdf
Peer-review Report	7596-Peer reviews.pdf
Scientific Editor Work List	7596-Scientific editor work list.pdf