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Articles Published Processes
8/25/2014 10:03:00 AM | Browse: 950 | Download: 1177
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Received |
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2013-11-26 13:47 |
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Peer-Review Started |
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2013-11-26 22:31 |
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To Make the First Decision |
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2014-01-16 08:24 |
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Return for Revision |
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2014-01-27 09:54 |
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Revised |
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Second Decision |
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2014-04-16 17:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-04-16 17:23 |
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Articles in Press |
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2014-05-23 09:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-06-13 21:01 |
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Publish the Manuscript Online |
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2014-06-16 15:44 |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Emerging role of protein kinase C in energy homeostasis: A brief overview
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kamal D Mehta |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
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| Corresponding Author |
Dr. Kamal D Mehta, Professor, Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Dorothy M Davis Heart and Lung Center, 1645 Neil Avenue, Columbus, OH 43210, United States. mehta.80@osu.edu |
| Key Words |
High-fat diet; Signal transduction; Obesity; Mitochondrial function; Insulin resistance |
| Core Tip |
Nutrition has important long-term conseque?nces for health. It is one of the lifestyle factors that contribute to the development and progression of obesity (increased fat accumulation), diabetes, and cardiovascular diseases. In fact, obesity rates are increasing dramatically worldwide and obesity amplifies the risk of developing various age-related chronic diseases, such as type 2 diabetes and cardiovascular disease. The prevention or management of chronic diseases is a global priority since they constitute a serious strain on health care systems and account for more than half of the deaths worldwide. Although correct lifestyle remains the mainstream solution to this problem, pharmacological strategies are also being actively seeked. Current antiobesity strategies have not controlled increasing epidemic of obesity and obesity-related disorders. We hope that a better knowledge of the molecular players and biochemical mechanism linking dietary fat to fat accumulation and development of glucose intolerance are critically needed. This review examines a way of metabolizing dietary fat into heat instead of storing them as fat, and the possibility that the “browning” of white fat is regulated by a diet-inducible kinase Protein kinase C-? (PKC?) may help us explore new translational approaches to combat obesity, improve insulin sensitivity and potentially increase longevity. Finally, attenuation of inflammation in fat by PKC? inhibition could have profound clinical consequences because of the large size of the fat organ and its central metabolic role. |
| Publish Date |
2014-06-16 15:44 |
| Citation |
Mehta KD. Emerging role of protein kinase C in energy homeostasis: A brief overview. World J Diabetes 2014; 5(3): 385-392 |
| URL |
http://www.wjgnet.com/1948-9358/full/v5/i3/385.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v5.i3.385 |
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