Publication Name	World Journal of Diabetes
Manuscript ID	7608
Country	Japan

Received	2013-11-26 14:04
Peer-Review Started	2013-11-26 23:08
To Make the First Decision	2014-02-13 16:15
Return for Revision	2014-02-18 20:39
Revised	2014-03-08 09:27
Second Decision	2014-04-17 14:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-17 15:19
Articles in Press	2014-05-23 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-13 21:02
Publish the Manuscript Online	2014-06-16 15:44

ISSN	1948-9358 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Clinical therapeutic strategies for early stage of diabetic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Munehiro Kitada, Keizo Kanasaki and Daisuke Koya
Funding Agency and Grant Number	Funding Agency Grant Number Novo Nordisk Pharma to Kitada M Grant-in-Aid for Scientific Research (C) 24591218 (to Kitada M) Promoted Research from Kanazawa Medical University S2012-4 (to Kitada M) Grant-in-Aid for Scientific Research (B) 25282028 (to Koya D) Grant-in-Aid for Challenging Exploratory Research 25670414 (to Koya D) grant for Specially Promoted Research from Kanazawa Medical University SR2012-06 (to Koya D) 4th Annual Research Award Grant of the Japanese Society of Anti-Aging Medicine to Koya D
Corresponding Author	Daisuke Koya, MD, PhD, Department of Diabetology and Endocrinology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa 920-0293, Japan. koya0516@kanazawa-med.ac.jp
Key Words	Diabetic kidney disease; Glycemic control; Renin-angiotensin system inhibitor; Multifactorial therapy; Remission and regression of albuminuria
Core Tip	We show the significance of targeting the remission/regression of microalbuminuria in type 2 diabetic patients, leading to protection against the progression of diabetic kidney disease (DKD) and cardiovascular events. To achieve the remission/regression of microalbuminuria, the multifactorial intervention and the early detection of microalbuminuria with continuous screening is important, as management of DKD. Multifactorial intervention includes glucose, blood pressure and lipid control. Additionally, other therapies, including vitamin D receptor activation, uric acid-lowering medicine and incretin-related medicines may be promising for preventing the progression of DKD. We review the current standard treatment for DKD and other prospective therapies for DKD.
Publish Date	2014-06-16 15:44
Citation	Kitada M, Kanasaki K, Koya D. Clinical therapeutic strategies for early stage of diabetic kidney disease. World J Diabetes 2014; 5(3): 342-356
URL	http://www.wjgnet.com/1948-9358/full/v5/i3/342.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i3.342

Full Article (PDF)	WJD-5-342.pdf
Full Article (Word)	WJD-5-342.doc
Manuscript File	7608-Review.docx
Answering Reviewers	7608-Answering reviewers.pdf
Copyright License Agreement	7608-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7608-Language certificate.pdf
Peer-review Report	7608-Peer review(s).pdf
Scientific Editor Work List	7608-Scientific editor work list.doc