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Articles Published Processes
9/23/2022 10:13:16 AM | Browse: 244 | Download: 571
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Received |
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2022-03-12 14:34 |
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Peer-Review Started |
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2022-03-12 14:35 |
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To Make the First Decision |
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Return for Revision |
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2022-06-11 04:01 |
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Revised |
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2022-06-20 12:06 |
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Second Decision |
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2022-09-01 04:03 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-09-01 18:50 |
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Articles in Press |
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2022-09-01 18:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-19 23:07 |
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Typeset the Manuscript |
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2022-09-02 01:24 |
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Publish the Manuscript Online |
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2022-09-23 10:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Review |
| Article Title |
P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Feng Jiang, Wei Wu, Han-Bing Hu, Zheng-Yang Li, Ming Zhong and Lin Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81801943 |
| Shanghai Pujiang Program |
21PJD009 |
| The Research Grant for Public Health Key Discipline of Shanghai Municipality |
GWV-10.1-XK26 |
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| Corresponding Author |
Lin Zhang, MD, PhD, Doctor, Doctor, Center of Emergency & Intensive Care Unit, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Shanghai 201508, China. linzhang0315@fudan.edu.cn |
| Key Words |
Intestinal barrier dysfunction; P2X7 receptor; T lymphocyte |
| Core Tip |
Intestinal barrier dysfunction is usually accompanied by inflammation and the death of epithelial cells, which may lead to an elevated concentration of extracellular adenosine triphosphate and the intestinal immune response. Meanwhile, available studies have demonstrated that P2X7 receptor (P2X7R) can be an important regulatory factor in the activation and differentiation of T cells, suggesting that P2X7R may play a key role in intestinal barrier disruption by regulating T cells. Therefore, in this review, we summarized the recent advances regarding the intestinal barrier, the role of P2X7R and T-cells in the pathophysiology of intestinal barrier disruption, and the role of T cell-derived P2X7R in the pathophysiology of intestinal barrier dysfunction. |
| Publish Date |
2022-09-23 10:13 |
| Citation |
Jiang ZF, Wu W, Hu HB, Li ZY, Zhong M, Zhang L. P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption. World J Gastroenterol 2022; 28(36): 5265-5279 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i36/5265.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i36.5265 |
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