| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Geoffroy Mallaret, Amandine Lashermes, Mathieu Meleine, Ludivine Boudieu, Julie Barbier, Youssef Aissouni, Agathe Gelot, Benoit Chassaing, Andrew T Gewirtz, Denis Ardid and Frederic Antonio Carvalho |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Region Auvergne-Rhône-Alpes and FEDER |
Thématiques émergentes |
| Region Auvergne-Rhône-Alpes and FEDER |
Pack Ambition Recherche |
| French Government IDEX-ISITE Initiative |
16-IDEX-0001-CAP 20-25 |
| Ministère de la Recherche et de la Technologie, INSERM and University of Clermont Auvergne |
UMR1071 |
|
| Corresponding Author |
Frederic Antonio Carvalho, PhD, Academic Research, Department of Pharmacology, INSERM 1107 NeuroDOL/University of Clermont Auvergne, 28 Place Henri Dunant, Clermont-Ferrand 63000, France. frederic.carvalho@inserm.fr |
| Key Words |
Chronic abdominal pain; Colonic hypersensitivity; Toll-like receptors; Intestinal microbiota; Early life events |
| Core Tip |
Neonatal maternal separation (NMS) model mimic deleterious events in childhood, which can induce a wide range of chronic disorders during adulthood. Herein, around 50% of NMS mice exhibited increased intestinal permeability and colonic hypersensitivity (CHS) associated with intestinal dysbiosis. Only toll-like receptor 5 (TLR5) mRNA expression was increased in colonocytes of NMS mice with CHS and acute intrarectal instillation of flagellin transiently increased intracolonic pressure variations, reflecting transient CHS appearance. Together, those findings suggest a pathophysiological continuum between intestinal permeability, intestinal dysbiosis and CHS, with a previously undescribed role for TLR5 in CHS. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Mallaret G, Lashermes A, Meleine M, Boudieu L, Barbier J, Aissouni Y, Gelot A, Chassaing B, Gewirtz AT, Ardid D, Carvalho FA. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. World J Gastroenterol 2022; 28(29): 3903-3916 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3903.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3903 |
