Publication Name	World Journal of Gastroenterology
Manuscript ID	76404
Country	France

Received	2022-03-15 09:39
Peer-Review Started	2022-03-15 09:42
First Decision by Editorial Office Director	2022-05-29 07:16
Return for Revision	2022-05-29 07:16
Revised	2022-06-09 05:09
Publication Fee Transferred
Second Decision by Editor	2022-07-01 03:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-07-06 03:01
Articles in Press	2022-07-06 03:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-25 04:59
Publish the Manuscript Online	2022-08-03 07:54

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation
Manuscript Source	Unsolicited Manuscript
All Author List	Geoffroy Mallaret, Amandine Lashermes, Mathieu Meleine, Ludivine Boudieu, Julie Barbier, Youssef Aissouni, Agathe Gelot, Benoit Chassaing, Andrew T Gewirtz, Denis Ardid and Frederic Antonio Carvalho
ORCID	Author(s) ORCID Number Geoffroy Mallaret http://orcid.org/0000-0002-3658-3418 Amandine Lashermes http://orcid.org/0000-0002-8241-464X Mathieu Meleine http://orcid.org/0000-0002-0925-087X Ludivine Boudieu http://orcid.org/0000-0002-4774-9313 Julie Barbier http://orcid.org/0000-0001-7177-3236 Youssef Aissouni http://orcid.org/0000-0002-9264-7690 Agathe Gelot http://orcid.org/0000-0002-7884-6968 Benoit Chassaing http://orcid.org/0000-0002-4285-769X Andrew T Gewirtz http://orcid.org/0000-0002-6338-7578 Denis Ardid http://orcid.org/0000-0003-4320-7338 Frederic Antonio Carvalho http://orcid.org/0000-0003-1592-2369
Funding Agency and Grant Number	Funding Agency Grant Number Region Auvergne-Rhône-Alpes and FEDER Thématiques émergentes Region Auvergne-Rhône-Alpes and FEDER Pack Ambition Recherche French Government IDEX-ISITE Initiative 16-IDEX-0001-CAP 20-25 Ministère de la Recherche et de la Technologie, INSERM and University of Clermont Auvergne UMR1071
Corresponding Author	Frederic Antonio Carvalho, PhD, Academic Research, Department of Pharmacology, INSERM 1107 NeuroDOL/University of Clermont Auvergne, 28 Place Henri Dunant, Clermont-Ferrand 63000, France. frederic.carvalho@inserm.fr
Key Words	Chronic abdominal pain; Colonic hypersensitivity; Toll-like receptors; Intestinal microbiota; Early life events
Core Tip	Neonatal maternal separation (NMS) model mimic deleterious events in childhood, which can induce a wide range of chronic disorders during adulthood. Herein, around 50% of NMS mice exhibited increased intestinal permeability and colonic hypersensitivity (CHS) associated with intestinal dysbiosis. Only toll-like receptor 5 (TLR5) mRNA expression was increased in colonocytes of NMS mice with CHS and acute intrarectal instillation of flagellin transiently increased intracolonic pressure variations, reflecting transient CHS appearance. Together, those findings suggest a pathophysiological continuum between intestinal permeability, intestinal dysbiosis and CHS, with a previously undescribed role for TLR5 in CHS.
Publish Date	2022-08-03 07:54
Citation	Mallaret G, Lashermes A, Meleine M, Boudieu L, Barbier J, Aissouni Y, Gelot A, Chassaing B, Gewirtz AT, Ardid D, Carvalho FA. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. World J Gastroenterol 2022; 28(29): 3903-3916
URL	https://www.wjgnet.com/1007-9327/full/v28/i29/3903.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i29.3903

Full Article (PDF)	WJG-28-3903.pdf
Full Article (Word)	WJG-28-3903.docx
Manuscript File	76404_Auto_Edited-LS.docx
Answering Reviewers	76404-Answering reviewers.pdf
Audio Core Tip	76404-Audio core tip.m4a
Biostatistics Review Certificate	76404-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	76404-Conflict-of-interest statement.pdf
Copyright License Agreement	76404-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	76404-Institutional animal care and use committee statement.pdf
Supplementary Material	76404-Supplementary material.pdf
Peer-review Report	76404-Peer-review(s).pdf
CrossCheck Report	76404-CrossCheck report.pdf