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7/27/2022 1:17:37 PM | Browse: 881 | Download: 2380
Publication Name World Journal of Hepatology
Manuscript ID 76510
Country India
Received
2022-03-23 13:17
Peer-Review Started
2022-03-23 13:19
First Decision by Editorial Office Director
2022-04-28 08:20
Return for Revision
2022-04-28 08:20
Revised
2022-05-13 09:03
Publication Fee Transferred
Second Decision by Editor
2022-06-29 03:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2022-07-06 22:08
Articles in Press
2022-07-06 22:08
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-18 00:35
Publish the Manuscript Online
2022-07-27 13:17
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease
Manuscript Source Invited Manuscript
All Author List Sagnik Biswas, Manas Vaishnav, Piyush Pathak, Deepak Gunjan, Soumya Jagannath Mahapatra, Saurabh Kedia, Gyanranjan Rout, Bhaskar Thakur, Baibaswata Nayak, Ramesh Kumar and Shalimar
ORCID
Author(s) ORCID Number
Sagnik Biswas http://orcid.org/0000-0003-3487-4921
Bhaskar Thakur http://orcid.org/0000-0001-6869-8968
Baibaswata Nayak http://orcid.org/0000-0003-2238-6015
Ramesh Kumar http://orcid.org/0000-0001-5136-4865
Shalimar http://orcid.org/0000-0003-1247-437X
Funding Agency and Grant Number
Corresponding Author Shalimar, MBBS, MD, Additional Professor, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, New Delhi 110029, Delhi, India. drshalimar@gmail.com
Key Words Gastrointestinal Hemorrhage; Platelet transfusion; Thrombocytopenia; Fresh frozen plasma; Portal hypertension; Mortality
Core Tip This is a retrospective study to assess the impact of thrombocytopenia at presentation and that of platelet transfusion in the management of acute variceal bleeding in patients with chronic liver disease. Ten percent of patients received platelet transfusions and were found to have significantly higher rebleed rates on day 5 and 42 after the index bleeding episode but did not result in significantly higher mortality rates in these patients. On multivariate analysis, platelet transfusion was an independent risk factor for 42-d rebleeding, while hepatic encephalopathy was a significant risk factor for 42-d mortality.
Publish Date 2022-07-27 13:17
Citation Biswas S, Vaishnav M, Pathak P, Gunjan D, Mahapatra SJ, Kedia S, Rout G, Thakur B, Nayak B, Kumar R, Shalimar. Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease. World J Hepatol 2022;14(7): 1421-1437
URL https://www.wjgnet.com/1948-5182/full/v14/i7/1421.htm
DOI https://dx.doi.org/10.4254/wjh.v14.i7.1421
Full Article (PDF) WJH-14-1421.pdf
Full Article (Word) WJH-14-1421.docx