Publication Name	World Journal of Clinical Cases
Manuscript ID	76534
Country	Slovenia

Received	2022-03-21 18:12
Peer-Review Started	2022-03-21 18:14
First Decision by Editorial Office Director	2022-04-25 21:22
Return for Revision	2022-04-26 12:41
Revised	2022-05-03 21:04
Publication Fee Transferred
Second Decision by Editor	2022-06-20 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-06-26 22:26
Articles in Press	2022-06-26 22:26
Edit the Manuscript by Language Editor	2022-05-23 10:39
Typeset the Manuscript	2022-06-30 08:39
Publish the Manuscript Online	2022-07-22 07:04

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hana Zavrtanik, Boštjan Luzar and Aleš Tomažič
ORCID	Author(s) ORCID Number Hana Zavrtanik http://orcid.org/0000-0003-0469-3978 Boštjan Luzar http://orcid.org/0000-0003-2534-8671 Aleš Tomažič http://orcid.org/0000-0002-1063-8636
Funding Agency and Grant Number
Corresponding Author	Aleš Tomažič, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloška cesta 7, Ljubljana 1000, Slovenia. ales.tomazic@kclj.si
Key Words	Ampulla of Vater; Neuroendocrine carcinoma; Mixed tumour; Pancreaticoduodenectomy; Prognosis; Case report
Core Tip	The ampulla of Vater is a transitional region with various distinctive histomorphologic characteristics, although the simultaneous occurrence of neuroendocrine and non-neuroendocrine tumors in this region is rare. When present, problems arise in differentiation between mixed neuroendocrine–non-neuroendocrine neoplasm and the collision of two distinct tumors. Due to the rarity of such tumors, their clinical behavior remains largely unknown, as do appropriate treatment measures. After radical resection, if feasible, the standard of care for the most aggressive and/or predominant component of the tumor from the same site of origin may be adopted. Newly diagnosed cases should be discussed at multidisciplinary team meetings to tailor postoperative treatment and follow-up appropriately.
Publish Date	2022-07-22 07:04
Citation	Zavrtanik H, Luzar B, Tomažič A. Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma: A case report. World J Clin Cases 2022; 10(22): 8045-8053
URL	https://www.wjgnet.com/2307-8960/full/v10/i22/8045.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i22.8045

Full Article (PDF)	WJCC-10-8045.pdf
Full Article (Word)	WJCC-10-8045.docx