Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	7666
Country	Italy

Received	2013-11-27 17:54
Peer-Review Started	2013-11-28 12:50
To Make the First Decision	2014-02-13 16:14
Return for Revision	2014-02-19 21:49
Revised	2014-05-30 17:03
Second Decision	2014-06-27 17:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-27 17:48
Articles in Press	2014-06-27 18:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-18 16:32
Publish the Manuscript Online	2014-08-19 17:22

ISSN	1948-5204 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	In vitro effects of polyphenols on colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	Barbara Pampaloni, Gaia Palmini, Carmelo Mavilia, Roberto Zonefrati, Annalisa Tanini and Maria Luisa Brandi
Funding Agency and Grant Number	Funding Agency Grant Number University of Florence
Corresponding Author	Maria Luisa Brandi, MD, PhD, Department of Surgery and Translational Medicine, University of Florence, Largo Palagi 1, Florence 50139, Italy. marialuisa.brandi@unifi.it
Key Words	Estrogen receptor; HCT8-?8 cells; HCT8-pSV2neo; Quercetin; Genistein
Core Tip	Colorectal cancer is one of the most common malignancies worldwide, though its incidence is lower in regions with a high dietary intake of estrogenic polyphenols. Moreover, the expression of estrogen receptor ? (ER?) is high in healthy colonic mucosa, and declines with the progression of colorectal cancer. This study examined the in vitro effects of two estrogenic polyphenols, quercetin and genistein, demonstrating their anti-proliferative effects and regulation of ER? activity and expression in colon cancer cells. These data suggest that a possible mechanism for the protective effects of such compounds is through activation and expression of ER?.
Publish Date	2014-08-19 17:22
Citation	Pampaloni B, Palmini G, Mavilia C, Zonefrati R, Tanini A, Brandi ML. In vitro effects of polyphenols on colorectal cancer cells. World J Gastrointest Oncol 2014; 6(8): 289-300
URL	http://www.wjgnet.com/1948-5204/full/v6/i8/289.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i8.289

Full Article (PDF)	WJGO-6-289.pdf
Full Article (Word)	WJGO-6-289.doc
Manuscript File	7666-Review.docx
Answering Reviewers	7666-Answering reviewers.pdf
Copyright License Agreement	7666-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7666-Language certificate.pdf
Scientific Misconduct Check	7666-CrossCheck.jpg
Scientific Editor Work List	7666-Scientific editor work list.pdf