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Articles Published Processes
10/25/2022 3:23:47 AM | Browse: 421 | Download: 1165
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Received |
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2022-05-05 02:00 |
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Peer-Review Started |
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2022-05-05 02:03 |
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To Make the First Decision |
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Return for Revision |
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2022-06-11 04:26 |
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Revised |
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2022-06-24 05:13 |
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Second Decision |
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2022-08-03 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-07 17:09 |
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Articles in Press |
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2022-08-07 17:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-09-27 16:47 |
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Typeset the Manuscript |
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2022-10-18 09:26 |
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Publish the Manuscript Online |
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2022-10-25 03:23 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Basic Study |
| Article Title |
Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ping Li, Yang Wang, Pei Li, Yuan-Lin Liu, Wei-Jiang Liu, Xiao-Yu Chen, Tian-Tian Tang, Ke-Min Qi and Yi Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (to P.L.) |
81602859 |
| National Natural Science Foundation of China (to P.L.) |
82173524 |
| National Key Research and Development Program of China (to Y.Z.) |
2016YFC1000305 |
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| Corresponding Author |
Yi Zhang, MD, PhD, Professor, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No. 27 Tai-ping Road, Beijing 100085, China. zhangyi612@hotmail.com |
| Key Words |
Calcium; Obesity; Bone mesenchymal stem cells; Wnt/β-Catenin signaling pathway; Adipogenic differentiation; Male offspring |
| Core Tip |
Maternal inappropriate dietary calcium intake during the pregnancy and lactation could aggravate the high-fat-diet-induced obesity with larger adipocytes, more serious inflammatory infiltration and higher serum metabolism indicators by disordering the expressions of related genes on the adipogenic differentiation in the adipose tissues among the male offspring. Meanwhile, it also showed the significantly different expressions of specific genes in the bone mesenchymal stem cells (BMSCs) to successfully polarize the adipogenic differentiation and suppress osteogenic differentiation in vivo and in vitro respectively. Furthermore, the related mechanistic insights were gained to worsen this differently adipogenic differentiation through the Wnt/β-Catenin signaling pathway both in the BMSCs and adulthood adipose tissues. The most worth mentioning of this study is that we have moved forward the preventive factors of the development of obesity such as the early-life appropriate calcium intake, which is not from the neonatal period, but from the period of maternal germ cells or fertilized egg formation. |
| Publish Date |
2022-10-25 03:23 |
| Citation |
Li P, Wang Y, Li P, Liu YL, Liu WJ, Chen XY, Tang TT, Qi KM, Zhang Y. Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells. World J Stem Cells 2022; 14(10): 756-776 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i10/756.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i10.756 |
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