Publication Name	World Journal of Biological Chemistry
Manuscript ID	7694
Country	United States

Received	2013-11-28 15:48
Peer-Review Started	2013-11-29 22:32
To Make the First Decision	2014-03-12 16:57
Return for Revision	2014-03-20 20:10
Revised	2014-03-21 06:23
Second Decision	2014-06-20 11:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-20 12:06
Articles in Press	2014-06-20 13:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-29 15:17
Publish the Manuscript Online	2014-09-11 10:03

ISSN	1949-8454 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	KAPtain in charge of multiple missions: Emerging roles of KAP1
Manuscript Source	Invited Manuscript
All Author List	Chun-Ting Cheng, Ching-Ying Kuo and David K Ann
Funding Agency and Grant Number
Corresponding Author	David K. Ann, Ph. D. Department of Molecular Pharmacology City of Hope Beckman Research Institute Duarte, CA 91010-3000 Tel: 626-359-8111 Ext. 64967 Fax: 626-471-7204 E-Mail: dann@coh.org
Key Words	KAP1; transcriptional co-repressor; post-translational modification; chromatin remodeling; KRAB-ZFP
Core Tip	This review article primarily summarizes the current findings of KAP1/TRIM28/TIF1β, with focuses on its biochemical and physiological functions. Both the canonical transcriptional co-repressor function and the transcriptional-independent roles of KAP1 are discussed in detail. We highlight the post-translational modifications and the compartmentalized localization of KAP1 and suggest that the function of KAP1 could be spatial and temporal regulated in multiple physiological circumstances. Finally, we summarize the clinical relevance of KAP1 in cancer and discuss the possibility to translate the mechanistic studies of KAP1 to human pathophysiology in the future.
Publish Date	2014-09-11 10:03
Citation	Cheng CT, Kuo CY, Ann DK. KAPtain in charge of multiple missions: Emerging roles of KAP1. World J Biol Chem 2014; 5(3): 308-320
URL	http://www.wjgnet.com/1949-8454/full/v5/i3/308.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i3.308

Full Article (PDF)	WJBC-5-308.pdf
Full Article (Word)	WJBC-5-308.doc
Manuscript File	7694-Review.docx
Answering Reviewers	7694-Answering reviewers.pdf
Copyright License Agreement	7694-Copyright assignment.pdf
Peer-review Report	7694-Peer review(s).pdf
Scientific Misconduct Check	7694-CrossCheck.jpg
Scientific Editor Work List	7694-Scientific editor work list.pdf