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Articles Published Processes
9/2/2022 6:17:50 AM | Browse: 269 | Download: 714
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Received |
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2022-04-14 11:54 |
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Peer-Review Started |
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2022-04-14 11:55 |
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To Make the First Decision |
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Return for Revision |
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2022-06-07 08:01 |
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Revised |
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2022-06-20 14:06 |
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Second Decision |
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2022-08-04 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-05 21:00 |
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Articles in Press |
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2022-08-05 21:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-10 00:49 |
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Publish the Manuscript Online |
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2022-09-02 06:17 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Case Report |
| Article Title |
Cytokine release syndrome complicated with rhabdomyolysis after chimeric antigen receptor T-cell therapy: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lan Zhang, Wei Chen, Xiao-Min Wang and Shu-Qing Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lan Zhang, Doctor, PhD, Assistant Professor, Department of Hematology, The First Hospital of Shanxi Medical University, No. 89 Xinjian Road, Taiyuan 030001, Shanxi Province, China. qiqi994@sina.com |
| Key Words |
Cytokine release syndrome; Rhabdomyolysis; Chimeric antigen receptor-T cell therapy; Relapsed acute lymphoblastic leukemia; Case report |
| Core Tip |
Cytokine release syndrome-induced rhabdomyolysis followed by chimeric antigen receptor-T (CAR-T) therapy treatment has not been previously reported. We report a case of a 22-year-old woman with relapsed acute lymphoblastic leukemia obtained sequential cluster of differentiation (CD) 19 and CD22 CAR-T cells infusion. This patient experienced grade 3 cytokine release syndrome with RM, mild hypotension requiring intravenous fluids, and mild hypoxia and was managed effectively with the interleukin-6 receptor antagonist tocilizumab. This patient had no signs of immune effector cell-associated neurologic syndrome. Restaging scans 30 d post CAR-T therapy demonstrated a complete remission, and the symptoms of muscle weakness improved through rehabilitation. Therefore, it is necessary to monitor myoglobin levels when a patient presents with symptoms of myalgia. |
| Publish Date |
2022-09-02 06:17 |
| Citation |
Zhang L, Chen W, Wang XM, Zhang SQ. Cytokine release syndrome complicated with rhabdomyolysis after chimeric antigen receptor T-cell therapy: A case report. World J Clin Cases 2022; 10(26): 9398-9403 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i26/9398.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i26.9398 |
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