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Articles Published Processes
8/31/2022 11:27:52 AM | Browse: 438 | Download: 1563
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Received |
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2022-04-20 21:55 |
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Peer-Review Started |
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2022-04-20 21:59 |
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To Make the First Decision |
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Return for Revision |
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2022-06-02 21:20 |
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Revised |
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2022-06-15 21:12 |
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Second Decision |
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2022-08-11 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-16 18:26 |
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Articles in Press |
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2022-08-16 18:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-05 04:10 |
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Typeset the Manuscript |
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2022-08-25 01:09 |
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Publish the Manuscript Online |
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2022-08-31 11:27 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Previous hepatitis B viral infection–underestimated cause of pancreatic cancer
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Manuscript Source |
Invited Manuscript |
All Author List |
Sergey Batskikh, Sergey Morozov, Alexey Dorofeev, Zanna Borunova, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva and Vladimir Chulanov |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Ministry of Science and Higher Education of Russian Federation |
FGMF-2022-0005 |
Russian Science Foundation |
20-15-00373 |
Moscow Healthcare Department |
AAAA-A18-118021590196-1 |
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Corresponding Author |
Sergey Morozov, MD, PhD, Doctor, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru |
Key Words |
Hepatitis B virus; Previous hepatitis B; Occult hepatitis B virus infection; Pancreatic cancer; Pancreatic ductal adenocarcinoma |
Core Tip |
Hepatitis B viral (HBV) infection is responsible for different types of cancer. However, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study aimed to assess the prevalence of previous HBV infection (PBI) and to identify viral biomarkers in patients with PDAC to support the role of the virus in etiology of this cancer. We found almost three-fold risks of PDAC in antibody to hepatitis B core antigen-positive patients. Detection of viral replication and HBx protein expression in the tumor tissue prove a possible involvement of HBV infection in pancreatic cancer development. PBI is currently an underestimated cause of PDAC. |
Publish Date |
2022-08-31 11:27 |
Citation |
Batskikh S, Morozov S, Dorofeev A, Borunova Z, Kostyushev D, Brezgin S, Kostyusheva A, Chulanov V. Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer. World J Gastroenterol 2022; 28(33): 4812-4822 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i33/4812.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i33.4812 |
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