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8/31/2022 11:27:52 AM | Browse: 281 | Download: 942
Publication Name World Journal of Gastroenterology
Manuscript ID 77236
Country/Territory Russia
Received
2022-04-20 21:55
Peer-Review Started
2022-04-20 21:59
To Make the First Decision
Return for Revision
2022-06-02 21:20
Revised
2022-06-15 21:12
Second Decision
2022-08-11 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-16 18:26
Articles in Press
2022-08-16 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-08-05 04:10
Typeset the Manuscript
2022-08-25 01:09
Publish the Manuscript Online
2022-08-31 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Previous hepatitis B viral infection–underestimated cause of pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Sergey Batskikh, Sergey Morozov, Alexey Dorofeev, Zanna Borunova, Dmitry Kostyushev, Sergey Brezgin, Anastasiya Kostyusheva and Vladimir Chulanov
ORCID
Author(s) ORCID Number
Sergey Batskikh http://orcid.org/0000-0002-5917-203X
Sergey Morozov http://orcid.org/0000-0001-6816-3058
Alexey Dorofeev http://orcid.org/0000-0001-9754-7579
Zanna Borunova http://orcid.org/0000-0001-5251-1513
Dmitry Kostyushev http://orcid.org/0000-0002-1851-7441
Sergey Brezgin http://orcid.org/0000-0003-4792-0739
Anastasiya Kostyusheva http://orcid.org/0000-0002-2335-6582
Vladimir Chulanov http://orcid.org/0000-0001-6303-9293
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Science and Higher Education of Russian Federation FGMF-2022-0005
Russian Science Foundation 20-15-00373
Moscow Healthcare Department AAAA-A18-118021590196-1
Corresponding Author Sergey Morozov, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru
Key Words Hepatitis B virus; Previous hepatitis B; Occult hepatitis B virus infection; Pancreatic cancer; Pancreatic ductal adenocarcinoma
Core Tip Hepatitis B viral (HBV) infection is responsible for different types of cancer. However, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study aimed to assess the prevalence of previous HBV infection (PBI) and to identify viral biomarkers in patients with PDAC to support the role of the virus in etiology of this cancer. We found almost three-fold risks of PDAC in antibody to hepatitis B core antigen-positive patients. Detection of viral replication and HBx protein expression in the tumor tissue prove a possible involvement of HBV infection in pancreatic cancer development. PBI is currently an underestimated cause of PDAC.
Publish Date 2022-08-31 11:27
Citation Batskikh S, Morozov S, Dorofeev A, Borunova Z, Kostyushev D, Brezgin S, Kostyusheva A, Chulanov V. Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer. World J Gastroenterol 2022; 28(33): 4812-4822
URL https://www.wjgnet.com/1007-9327/full/v28/i33/4812.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i33.4812
Full Article (PDF) WJG-28-4812.pdf
Full Article (Word) WJG-28-4812.docx
Manuscript File 77236_Auto_Edited-LM.docx
Answering Reviewers 77236-Answering reviewers.pdf
Audio Core Tip 77236-Audio core tip.mp3
Biostatistics Review Certificate 77236-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 77236-Conflict-of-interest statement.pdf
Copyright License Agreement 77236-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 77236-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 77236-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 77236-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 77236-Language certificate.pdf
Peer-review Report 77236-Peer-review(s).pdf
Scientific Misconduct Check 77236-Bing-Fan JR-2.png
Scientific Editor Work List 77236-Scientific editor work list.pdf