Publication Name	World Journal of Biological Chemistry
Manuscript ID	7729
Country	Germany

Received	2013-11-30 11:39
Peer-Review Started	2013-11-30 23:17
To Make the First Decision	2014-02-27 11:32
Return for Revision	2014-03-03 17:42
Revised	2014-03-13 06:08
Second Decision	2014-04-11 18:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-11 19:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-22 14:39
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Functional analysis of human Na+/K+-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes
Manuscript Source	Invited Manuscript
All Author List	Susan Spiller and Thomas Friedrich
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation (Cluster of Excellence “Unifying Concepts in Catalysis”)
Corresponding Author	Thomas Friedrich, Professor, Institute of Chemistry, Technical University of Berlin, Sekr. PC-14, Straβe des 17. Juni 135, D-10623 Berlin, Germany. friedrich@chem.tu-berlin.de
Key Words	Na+/K+-ATPase; Electrophysiology; Voltage dependence; Familial hemiplegic migraine; C-terminus; β-subunit
Core Tip	Mutations of the human ATP1A2 gene, which encodes the Na+/K+-ATPase α2-subunit, are associated with familial hemiplegic migraine (FHM2) that is inherited in an autosomal dominant fashion. We studied seven ATP1A2 mutations related to FHM2 or sporadic hemiplegic migraine by electrophysiological and biochemical methods to characterize functional impairments. The mutations G855R, G900R, E902K, L994del, D999H, K1003E and Y1009X were selected according to their structural importance: in putative interaction sites between α- and β-subunit and in the α-subunit’s C-terminal region. Some of these mutations showed a severe loss of function, and we discuss the functional and physiological consequences in order to better understand the molecular basis for neurological impairments.
Publish Date	2014-06-11 10:30
Citation	Spiller S, Friedrich T. Functional analysis of human Na+/K+-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes. World J Biol Chem 2014; 5(2): 240-253
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/240.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.240

Full Article (PDF)	wjbc-5-240.pdf
Full Article (Word)	wjbc-5-240.doc
Manuscript File	7729-Review.docx
Answering Reviewers	7729-Answering reviewers.pdf
Copyright License Agreement	7729-Copyright assignment.pdf
Peer-review Report	7729-Peer review(s).pdf
Scientific Editor Work List	7729-Scientific editor work list.doc