BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/31/2022 11:27:51 AM | Browse: 589 | Download: 1842
 |
Received |
|
2022-05-12 10:49 |
|
Peer-Review Started |
|
2022-05-12 10:53 |
|
First Decision by Editorial Office Director |
|
2022-06-19 04:54 |
|
Return for Revision |
|
2022-06-19 04:54 |
|
Revised |
|
2022-07-06 18:36 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2022-08-11 02:57 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2022-08-16 17:49 |
|
Articles in Press |
|
2022-08-16 17:49 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-08-25 01:23 |
|
Publish the Manuscript Online |
|
2022-08-31 11:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jana Maslankova, Ivana Vecurkovska, Miroslava Rabajdova, Jana Katuchova, Milos Kicka, Michala Gayova and Vladimir Katuch |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Jana Katuchova, MD, PhD, Doctor, Doctor, Professor, Surgeon, First Department of Surgery, Medical Faculty of Safarik University, 1 Trieda SNP, Kosice 04011, Kosicky kraj, Slovakia. jana.katuchova@upjs.sk |
| Key Words |
Small mothers against decapentaplegic homologs; Transforming growth factor-beta; Colorectal cancer; Marker; Signaling pathway |
| Core Tip |
A thorough understanding of the complete transforming growth factor (TGF)-β/small mothers against decapentaplegic homolog (SMAD) signaling pathway is important for defining its functions during pathological processes of colorectal cancer (CRC). Inhibitors specifically targeting TGF-β pathway mediators that reduce the expression of a particular protein may lead to fewer/milder adverse effects. However, the dual role of the TGF-β pathway in the onset and progression of cancer complicates the physiological/pathological and, thus, clinical situation. In recent years, research has shown that modification of members of this pathway is a promising approach for clinical procedures. Long-term treatment should emphasize personalized and targeted therapy. |
| Publish Date |
2022-08-31 11:27 |
| Citation |
Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i33/4744.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i33.4744 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
