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Articles Published Processes
8/31/2022 11:27:51 AM | Browse: 386 | Download: 1104
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Received |
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2022-05-12 10:49 |
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Peer-Review Started |
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2022-05-12 10:53 |
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To Make the First Decision |
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Return for Revision |
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2022-06-19 04:54 |
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Revised |
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2022-07-06 18:36 |
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Second Decision |
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2022-08-11 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-16 17:49 |
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Articles in Press |
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2022-08-16 17:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-25 01:23 |
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Publish the Manuscript Online |
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2022-08-31 11:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jana Maslankova, Ivana Vecurkovska, Miroslava Rabajdova, Jana Katuchova, Milos Kicka, Michala Gayova and Vladimir Katuch |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jana Katuchova, MD, PhD, Doctor, Doctor, Professor, Surgeon, First Department of Surgery, Medical Faculty of Safarik University, 1 Trieda SNP, Kosice 04011, Kosicky kraj, Slovakia. jana.katuchova@upjs.sk |
| Key Words |
Small mothers against decapentaplegic homologs; Transforming growth factor-beta; Colorectal cancer; Marker; Signaling pathway |
| Core Tip |
A thorough understanding of the complete transforming growth factor (TGF)-β/small mothers against decapentaplegic homolog (SMAD) signaling pathway is important for defining its functions during pathological processes of colorectal cancer (CRC). Inhibitors specifically targeting TGF-β pathway mediators that reduce the expression of a particular protein may lead to fewer/milder adverse effects. However, the dual role of the TGF-β pathway in the onset and progression of cancer complicates the physiological/pathological and, thus, clinical situation. In recent years, research has shown that modification of members of this pathway is a promising approach for clinical procedures. Long-term treatment should emphasize personalized and targeted therapy. |
| Publish Date |
2022-08-31 11:27 |
| Citation |
Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i33/4744.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i33.4744 |
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