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Articles Published Processes
11/24/2022 12:34:51 PM | Browse: 342 | Download: 705
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Received |
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2022-05-03 01:28 |
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Peer-Review Started |
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2022-05-03 01:29 |
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To Make the First Decision |
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Return for Revision |
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2022-06-08 10:32 |
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Revised |
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2022-06-27 14:23 |
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Second Decision |
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2022-11-02 03:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-11-03 04:27 |
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Articles in Press |
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2022-11-03 04:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-09-28 17:34 |
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Typeset the Manuscript |
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2022-11-08 09:29 |
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Publish the Manuscript Online |
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2022-11-24 12:34 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Minireviews |
| Article Title |
Haemochromatosis revisited
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aline Morgan Alvarenga, Pierre Brissot and Paulo Caleb Junior Lima Santos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Paulo Caleb Junior Lima Santos, PhD, Adjunct Professor, Department of Pharmacology - Escola Paulista de Medicina (EPM-Unifesp), Universidade Federal de São Paulo, Adress: 03 de Maio St., 100. INFAR, 4° andar - Vila Clementino - São Paulo, SP, São Paulo 04044-020, São Paulo, Brazil. paulo.caleb@unifesp.br |
| Key Words |
Haemochromatosis; Iron overload; HFE; Molecular diagnosis; Hepcidin |
| Core Tip |
Haemochromatosis is a genetic disease caused by hepcidin deficiency, responsible for an increase in intestinal iron absorption. Haemochromatosis is associated with homozygosity for the HFE p.Cys282Tyr mutation. However, rare cases of haemochromatosis (non-HFE haemochromatosis) can also be caused by pathogenic variants in other genes (such as HJV, HAMP, TFR2 and SLC40A1). A working group of the International Society for the Study of Iron in Biology and Medicine (BIOIRON Society) has concluded that classification based on different molecular subtypes is difficult to be adopted in clinical practice and has proposed a new classification approaching clinical questions and molecular complexity. The aim of the present review is to provide an update on classification, pathophysiology and therapeutic recommendations. |
| Publish Date |
2022-11-24 12:34 |
| Citation |
Alvarenga AM, Brissot P, Santos PCJ. Haemochromatosis revisited. World J Hepatol 2022; 14(11): 1931-1939 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i11/1931.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i11.1931 |
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