Publication Name	World Journal of Gastroenterology
Manuscript ID	77652
Country	Spain

Received	2022-05-12 11:24
Peer-Review Started	2022-05-12 11:26
To Make the First Decision
Return for Revision	2022-05-28 22:50
Revised	2022-05-31 10:20
Second Decision	2022-07-15 03:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-18 21:33
Articles in Press	2022-07-18 21:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-03 04:54
Publish the Manuscript Online	2022-08-10 08:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biology
Manuscript Type	Letter to the Editor
Article Title	Alcohol-related diseases and liver metastasis: Role of cell-free network communication
Manuscript Source	Unsolicited Manuscript
All Author List	Manuel Muro, Aurelia Collados-Ros and Isabel Legaz
ORCID	Author(s) ORCID Number Manuel Muro http://orcid.org/0000-0001-9987-0994 Isabel Legaz http://orcid.org/0000-0002-1140-4313
Funding Agency and Grant Number
Corresponding Author	Isabel Legaz, PhD, Senior Lecturer, Department of Legal and Forensic Medicine, Biomedical Research Institute (IMIB), Regional Campus of International Excellence “Campus Mare Nostrum”, Faculty of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain. isalegaz@um.es
Key Words	Exosomes; Liver metastasis; Alcohol-associated liver disease; Cancer
Core Tip	In this letter to the editor, we discussed the reality that alcohol consumption is a risk factor that acts by itself to favor the appearance of the carcinogenic process and its harmful evolution towards metastatic pathology. One of the hypotheses that have been suggested as important in metastasis and communication between cells and/or organs is the traffic of extracellular vesicles/exosomes that can play or promote tumorigenesis locally and even at a distance from the primary tumor. Unraveling these communication mechanisms and therapeutic possibilities may lead to new ways to combat cancer’s worsening, as metastasis, in the future.
Publish Date	2022-08-10 08:23
Citation	Muro M, Collados-Ros A, Legaz I. Alcohol-related diseases and liver metastasis: Role of cell-free network communication. World J Gastroenterol 2022; 28(30): 4231-4234
URL	https://www.wjgnet.com/1007-9327/full/v28/i30/4231.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i30.4231

Full Article (PDF)	WJG-28-4231.pdf
Full Article (Word)	WJG-28-4231.docx
Manuscript File	77652_Auto_Edited_LM.docx
Answering Reviewers	77652-Answering reviewers.pdf
Audio Core Tip	77652-Audio core tip.wav
Conflict-of-Interest Disclosure Form	77652-Conflict-of-interest statement.pdf
Copyright License Agreement	77652-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	77652-Language certificate.pdf
Peer-review Report	77652-Peer-review(s).pdf
Scientific Misconduct Check	77652-Bing-Chen YL-2.jpg
Scientific Editor Work List	77652-Scientific editor work list.pdf