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Articles Published Processes
10/14/2022 12:54:50 PM | Browse: 383 | Download: 1269
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Received |
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2022-05-19 16:17 |
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Peer-Review Started |
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2022-05-19 16:20 |
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To Make the First Decision |
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Return for Revision |
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2022-06-06 13:44 |
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Revised |
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2022-06-20 18:35 |
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Second Decision |
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2022-09-19 03:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-09-21 18:05 |
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Articles in Press |
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2022-09-21 18:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-09-07 13:20 |
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Typeset the Manuscript |
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2022-09-27 15:55 |
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Publish the Manuscript Online |
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2022-10-14 12:54 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression of ELL-associated factor 2 suppresses invasion, migration, and angiogenesis in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Liang Feng, Can Wu, Hui-Jing Zhang, Huan Zhou, Tai-Wei Jiao, Meng-Yuan Liu and Ming-Jun Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
2019-BS-279 |
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| Corresponding Author |
Ming-Jun Sun, Doctor, PhD, Chief Physician, Professor, Department of Endoscopy, The First Hospital Affiliated to China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. sunydyy@163.com |
| Key Words |
ELL-associated factor 2; Transforming growth factor-β1; Signal transducer and activator of transcription 3; Colorectal cancer; Invasion; Migration; Angiogenesis |
| Core Tip |
Androgen-responsive gene ELL-associated factor 2 (EAF2) plays an important role in tumor suppression in a variety of malignant tumors. We found that EAF2 protein was lowly expressed in colorectal cancer (CRC) tissues. Kaplan-Meier survival analysis showed that the survival rate of the group with high EAF2 level was higher than that of the group with low EAF2 level. Moreover, EAF2 may play a tumor suppressive and protective role in CRC by inhibiting the invasion, metastasis, and angiogenesis via regulating the signal transducer and activator of transcription 3/transforming growth factor beta 1 crosstalk pathway. Our findings are of great significance to provide a new idea and theoretical basis for targeting diagnosis and therapy of CRC. |
| Publish Date |
2022-10-14 12:54 |
| Citation |
Feng ML, Wu C, Zhang HJ, Zhou H, Jiao TW, Liu MY, Sun MJ. Overexpression of ELL-associated factor 2 suppresses invasion, migration, and angiogenesis in colorectal cancer. World J Gastrointest Oncol 2022; 14(10): 1949-1967 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i10/1949.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i10.1949 |
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