Publication Name	World Journal of Stem Cells
Manuscript ID	77808
Country	China

Received	2022-05-23 01:30
Peer-Review Started	2022-05-23 01:32
To Make the First Decision
Return for Revision	2022-07-06 22:47
Revised	2022-07-18 11:12
Second Decision	2022-09-05 03:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-06 19:29
Articles in Press	2022-09-06 19:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-31 07:27
Typeset the Manuscript	2022-09-20 01:35
Publish the Manuscript Online	2022-09-23 09:45

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Xia Tang, Bing Wei, Lu-Yao Jiang, You-You Ying, Ke Li, Tian-Xi Chen, Ruo-Fei Huang, Miao-Jun Shi and Hang Xu
ORCID	Author(s) ORCID Number Li-Xia Tang http://orcid.org/0000-0002-5429-9146 Bing Wei http://orcid.org/0000-0002-3398-8364 Lu-Yao Jiang http://orcid.org/0000-0002-7745-2676 You-You Ying http://orcid.org/0000-0001-5502-9087 Ke Li http://orcid.org/0000-0002-4762-7711 Tian-Xi Chen http://orcid.org/0000-0003-2112-3600 Ruo-Fei Huang http://orcid.org/0000-0002-3032-7886 Miao-Jun Shi http://orcid.org/0000-0001-9772-9268 Hang Xu http://orcid.org/0000-0001-6304-5693
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Foundation of Jinhua 2021-4-190
Corresponding Author	Hang Xu, BMed, Doctor, Doctor, Occupational Physician, Department of Hemodialysis/Nephrology, The First People’s Hospital of Yongkang Affiliated to Hangzhou Medical College, No. 599, Jinshan West Road, Dongcheng District, Jinhua 321300, Zhejiang Province, China. 13758989843@163.com
Key Words	Mitochondria transfer; Mesenchymal stem cells; Glomerular endothelial cells; Diabetic kidney disease; Mitochondrial dysfunction; Oxidative stress
Core Tip	This study demonstrated that the MitoTracker Red CMXRos labeled mitochondria were transferred from mesenchymal stem cells (MSCs) to the high glucose-injured glomerular endothelial cells (GECs) in vitro. Additionally, GEC proliferation was enhanced, and GEC apoptosis was suppressed. Furthermore, in vivo experiments showed that MSCs ameliorated renal function damage and pathological progression of diabetic kidney disease (DKD). These data suggest that MSCs may rescue damaged GECs and improve the renal function and pathological changes of DKD partly through mitochondrial transfer.
Publish Date	2022-09-23 09:45
Citation	Tang LX, Wei B, Jiang LY, Ying YY, Li K, Chen TX, Huang RF, Shi MJ, Xu H. Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells. World J Stem Cells 2022; 14(9): 729-743
URL	https://www.wjgnet.com/1948-0210/full/v14/i9/729.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i9.729

Full Article (PDF)	WJSC-14-729.pdf
Full Article (Word)	WJSC-14-729.docx
The ARRIVE Guidelines	77808-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	77808_Auto_Edited-LM.docx
Answering Reviewers	77808-Answering reviewers.pdf
Audio Core Tip	77808-Audio core tip.mp3
Biostatistics Review Certificate	77808-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77808-Conflict-of-interest statement.pdf
Copyright License Agreement	77808-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77808-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	77808-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	77808-Language certificate.pdf
Supplementary Material	77808-Supplementary material.pdf
Peer-review Report	77808-Peer-review(s).pdf
Scientific Misconduct Check	77808-Bing-Wang JJ-2.png
Scientific Editor Work List	77808-Scientific editor work list.pdf
CrossCheck Report	77808-CrossCheck report.pdf