Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	78040
Country	Egypt

Received	2022-06-03 18:36
Peer-Review Started	2022-06-03 18:37
To Make the First Decision
Return for Revision	2022-06-27 10:21
Revised	2022-07-29 22:45
Second Decision	2022-09-14 03:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-14 17:36
Articles in Press	2022-09-14 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-05 11:42
Typeset the Manuscript	2022-10-09 07:20
Publish the Manuscript Online	2022-10-12 07:58

ISSN	1948-5190 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Cronkhite-Canada syndrome: First case report from Egypt and North Africa
Manuscript Source	Unsolicited Manuscript
All Author List	Ahmed Elsayed Alzamzamy, Ashraf Aboubakr, Hussein H Okasha, Abeer Abdellatef, Shaimaa Elkholy, Mahmoudd Wahba, Mohamed Alboraie, Hussein Elsayed and Mohamed O Othman
ORCID	Author(s) ORCID Number Ahmed Elsayed Alzamzamy http://orcid.org/0000-0002-3817-5370 Ashraf Aboubakr http://orcid.org/0000-0002-3453-9317 Hussein H Okasha http://orcid.org/0000-0002-0815-1394 Abeer Abdellatef http://orcid.org/0000-0001-9945-9767 Shaimaa Elkholy http://orcid.org/0000-0003-4322-6467 Mohamed O Othman http://orcid.org/0000-0002-5888-4334
Funding Agency and Grant Number
Corresponding Author	Ahmed Elsayed Alzamzamy, MD, PhD, Consultant Physician-Scientist, Senior Lecturer, Department of Gastroenterology and Hepatology, Maadi Armed Forces Medical Complex, Military Medical Academy, Maadi Kornich El Nile, Cairo 11711, Egypt. dr_zamzamy@hotmail.com
Key Words	Case report; Cronkhite-Canada syndrome; Thickened gastric mucosa; Gastrointestinal polyposis
Core Tip	Cronkhite-Canada syndrome (CCS) is a rare acquired polyposis with unknown aetiology. To date about 500 cases have been reported worldwide, we reported an Egyptian patient of CCS. Most of CCS were reported from Japan, and for our knowledge, our case is the 1st case reported from Egypt and North Africa. Cases presented with gastrointestinal (GI) polyposis and marked thickened gastric mucosa and folds represent challenging cases and diagnostic dilemmas. The diagnosis was based on history, physical examination, endoscopic findings, and the histology. CCS is typically characterized by GI symptoms, such as diarrhea and skin changes (e.g., alopecia, pigmentation, and nail dystrophy), while endoscopic features include diffuse polyps throughout the entire GIT, except for the esophagus. Pathological types of polyps in CCS mainly include inflammatory, hyperplastic, hamartomatous, and/or adenomatous polyps. CCS can be complicated by many diseases and has a malignant tendency with a high mortality rate. There is no uniform standard treatment for CCS.
Publish Date	2022-10-12 07:58
Citation	Alzamzamy AE, Aboubakr A, Okasha HH, Abdellatef A, Elkholy S, Wahba M, Alboraie M, Elsayed H, Othman MO. Cronkhite-Canada syndrome: First case report from Egypt and North Africa. World J Gastrointest Endosc 2022; 14(10): 642-647
URL	https://www.wjgnet.com/1948-5190/full/v14/i10/642.htm
DOI	https://dx.doi.org/10.4253/wjge.v14.i10.642

Full Article (PDF)	WJGE-14-642.pdf
Full Article (Word)	WJGE-14-642.docx
CARE Checklist–2016	78040-CARE-Checklist–2016-revision.pdf
Manuscript File	78040_Auto_Edited-LM_WangTQ.docx
Answering Reviewers	78040-Answering reviewers.pdf
Audio Core Tip	78040-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	78040-Conflict-of-interest statement.pdf
Copyright License Agreement	78040-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	78040-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	78040-Language certificate.pdf
Peer-review Report	78040-Peer-review(s).pdf
Scientific Misconduct Check	78040-Bing-Chen YL-2.png
Scientific Editor Work List	78040-Scientific editor work list.pdf
CrossCheck Report	78040-CrossCheck report.pdf