Publication Name	World Journal of Clinical Cases
Manuscript ID	78168
Country	China

Received	2022-06-14 04:04
Peer-Review Started	2022-06-12 08:14
To Make the First Decision
Return for Revision	2022-07-29 04:58
Revised	2022-09-04 03:56
Second Decision	2022-10-10 03:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-11 00:14
Articles in Press	2022-10-11 00:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-09 08:40
Typeset the Manuscript	2022-10-14 05:39
Publish the Manuscript Online	2022-11-08 07:44

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathogenesis of adherent invasive Escherichia coli and its role in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lie Zheng, Sheng-Lei Duan and Yan-Cheng Dai
ORCID	Author(s) ORCID Number Lie Zheng http://orcid.org/0000-0002-0918-0728 Sheng-Lei Duan http://orcid.org/0000-0003-2001-9916 Yan-Cheng Dai http://orcid.org/0000-0002-4754-1897
Funding Agency and Grant Number	Funding Agency Grant Number General Research of Xi’an Science and Technology Planning Project 2022JH-YBYJ-0265 Shaanxi Province Natural Science Basic Research Program-General Project 2019JM-580 Project of Shaanxi Administration of Traditional Chinese Medicine 2019-ZZ-JC010 Shaanxi Provincial Hospital of Traditional Chinese Medicine 2018-04 Shaanxi Provincial Hospital of Traditional Chinese Medicine 2021-07
Corresponding Author	Lie Zheng, PhD, Chairman, Research Scientist, Department of Gastroenterology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 4 Xihuamen, Xi’an 322000, Shaanxi Province, China. 492688049@qq.com
Key Words	Adherent invasive Escherichia coli; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Prevention
Core Tip	Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but no single pathogenic microorganism critical to IBD, that is specific to the IBD terminal ileum mucosa, or can invade intestinal epithelial cells (IECs) has been found. Invasive E. coli adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel disease. Further study of the specific biological characteristics of adherent invasive E. coli (AIEC) may contribute to further understanding of IBD pathogenesis. This review explores the relationship between AIEC and the intestinal immune system, discusses the prevalence and correlation of AIEC in Crohn's disease (CD) and ulcerative colitis (UC) patients, and describes the relationship between AIEC and the disease site, activity and postoperative recurrence. Finally, we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa, including the use of phage therapy, antibiotics, and anti-adhesion molecules. These strategies may open up new avenues for the prevention and treatment of IBD in the future.
Publish Date	2022-11-08 07:44
Citation	Zheng L, Duan SL, Dai YC, Wu SC. Role of adherent invasive Escherichia coli and its role in inflammatory bowel disease. World J Clin Cases 2022; 10(32): 11671-11689
URL	https://www.wjgnet.com/2307-8960/full/v10/i32/11671.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i32.11671

Full Article (PDF)	WJCC-10-11671.pdf
Full Article (Word)	WJCC-10-11671.docx
Manuscript File	78168_Auto_Edited-LLW-WangTQ-JLW.docx
Answering Reviewers	78168-Answering reviewers.pdf
Audio Core Tip	78168-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	78168-Conflict-of-interest statement.pdf
Copyright License Agreement	78168-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78168-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	78168-Language certificate.pdf
Peer-review Report	78168-Peer-review(s).pdf
Scientific Misconduct Check	78168-Bing-Wang LL-2.png
Scientific Editor Work List	78168-Scientific editor work list.pdf
CrossCheck Report	78168-CrossCheck report.pdf