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11/8/2022 7:44:25 AM | Browse: 231 | Download: 788
Publication Name World Journal of Clinical Cases
Manuscript ID 78168
Country/Territory China
Received
2022-06-14 04:04
Peer-Review Started
2022-06-12 08:14
To Make the First Decision
Return for Revision
2022-07-29 04:58
Revised
2022-09-04 03:56
Second Decision
2022-10-10 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-10-11 00:14
Articles in Press
2022-10-11 00:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-10-09 08:40
Typeset the Manuscript
2022-10-14 05:39
Publish the Manuscript Online
2022-11-08 07:44
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Pathogenesis of adherent invasive Escherichia coli and its role in inflammatory bowel disease
Manuscript Source Invited Manuscript
All Author List Lie Zheng, Sheng-Lei Duan and Yan-Cheng Dai
ORCID
Author(s) ORCID Number
Lie Zheng http://orcid.org/0000-0002-0918-0728
Sheng-Lei Duan http://orcid.org/0000-0003-2001-9916
Yan-Cheng Dai http://orcid.org/0000-0002-4754-1897
Funding Agency and Grant Number
Funding Agency Grant Number
General Research of Xi’an Science and Technology Planning Project 2022JH-YBYJ-0265
Shaanxi Province Natural Science Basic Research Program-General Project 2019JM-580
Project of Shaanxi Administration of Traditional Chinese Medicine 2019-ZZ-JC010
Shaanxi Provincial Hospital of Traditional Chinese Medicine 2018-04
Shaanxi Provincial Hospital of Traditional Chinese Medicine 2021-07
Corresponding Author Lie Zheng, PhD, Chairman, Research Scientist, Department of Gastroenterology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 4 Xihuamen, Xi’an 322000, Shaanxi Province, China. 492688049@qq.com
Key Words Adherent invasive Escherichia coli; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Prevention
Core Tip Gut microbiota imbalances play an important role in inflammatory bowel disease (IBD), but no single pathogenic microorganism critical to IBD, that is specific to the IBD terminal ileum mucosa, or can invade intestinal epithelial cells (IECs) has been found. Invasive E. coli adhesion to macrophages is considered to be closely related to the pathogenesis of inflammatory bowel disease. Further study of the specific biological characteristics of adherent invasive E. coli (AIEC) may contribute to further understanding of IBD pathogenesis. This review explores the relationship between AIEC and the intestinal immune system, discusses the prevalence and correlation of AIEC in Crohn's disease (CD) and ulcerative colitis (UC) patients, and describes the relationship between AIEC and the disease site, activity and postoperative recurrence. Finally, we highlight potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa, including the use of phage therapy, antibiotics, and anti-adhesion molecules. These strategies may open up new avenues for the prevention and treatment of IBD in the future.
Publish Date 2022-11-08 07:44
Citation Zheng L, Duan SL, Dai YC, Wu SC. Role of adherent invasive Escherichia coli and its role in inflammatory bowel disease. World J Clin Cases 2022; 10(32): 11671-11689
URL https://www.wjgnet.com/2307-8960/full/v10/i32/11671.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i32.11671
Full Article (PDF) WJCC-10-11671.pdf
Full Article (Word) WJCC-10-11671.docx
Manuscript File 78168_Auto_Edited-LLW-WangTQ-JLW.docx
Answering Reviewers 78168-Answering reviewers.pdf
Audio Core Tip 78168-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 78168-Conflict-of-interest statement.pdf
Copyright License Agreement 78168-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 78168-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 78168-Language certificate.pdf
Peer-review Report 78168-Peer-review(s).pdf
Scientific Misconduct Check 78168-Bing-Wang LL-2.png
Scientific Editor Work List 78168-Scientific editor work list.pdf