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Articles Published Processes
9/29/2022 9:17:29 AM | Browse: 418 | Download: 1213
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Received |
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2022-07-02 13:16 |
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Peer-Review Started |
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2022-07-02 13:18 |
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To Make the First Decision |
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Return for Revision |
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2022-08-01 08:21 |
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Revised |
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2022-08-14 13:59 |
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Second Decision |
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2022-08-29 03:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-30 22:17 |
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Articles in Press |
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2022-08-30 22:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-23 10:06 |
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Publish the Manuscript Online |
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2022-09-29 09:17 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Zhang, Ting Sun, Xiao-Ye Wu, Fa-Ming Fei and Zhen-Zhen Gao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhen-Zhen Gao, MD, PhD, Director, Director, Department of Clinical Oncology, The Second Affiliated Hospital of Jiaxing University, No. 1518 Huancheng Road, Jiaxing 314000, Zhejiang Province, China. sarrah0112@163.com |
| Key Words |
Hepatocellular carcinoma; SMARCA4; Prognosis; Immune infiltration; Competing endogenous RNA |
| Core Tip |
Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and the mortality rate continues to rise each year. SMARCA4 expression has been associated with poor prognosis in various types of cancer; however, the specific mechanism of action of SMARCA4 in HCC needs to be fully elucidated. To date, only few studies have successfully elucidated the mechanism of action of SMARCA4 in the progression of HCC. In the present study, we aimed to establish a SMARCA4-related competing endogenous RNA (ceRNA) network by mapping and analyzing the transcription profiles of SMARCA4 in HCC. we observed the overexpression of SMARCA4 in different pathways. Additionally, the overexpression of SMARCA4 was correlated to an increased immune cell infiltration and an augmented sensitivity to immunotherapy. Furthermore, a novel SMARCA4 ceRNA network (SNHG3/THUMP3-AS1-miR-139-5p-SMARCA4) was established in this study. This study could contribute towards the identification of predictive markers for immunotherapy and a novel mechanism of action for HCC treatment. |
| Publish Date |
2022-09-29 09:17 |
| Citation |
Zhang L, Sun T, Wu XY, Fei FM, Gao ZZ. Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma. World J Clin Cases 2022; 10(29): 10501-10515 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i29/10501.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i29.10501 |
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