| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Curcumin alleviates experimental colitis via a potential mechanism involving memory B cells and Bcl-6-Syk-BLNK signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Yi Wei, Tian-Tian Wu, Jia-Qi Huang, Zeng-Ping Kang, Meng-Xue Wang, You-Bao Zhong, Wei Ge, Bu-Gao Zhou, Hai-Mei Zhao, Hai-Yan Wang and Duan-Yong Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81760808 |
| Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program |
CXTD22008 |
|
| Corresponding Author |
Duan-Yong Liu, PhD, Director, Director, Full Professor, Professor, Formula-Pattern Research Center, Jiangxi University of Chinese Medicine, No. 1688 Meiling Road, Nanchang 330004, Jiangxi Province, China. liuduanyong@163.com |
| Key Words |
Curcumin; Experimental colitis; Memory B cell; Bcl-6; BLNK |
| Core Tip |
As the precursor of B cells, the activation of memory B cells can trigger the activation of B cells, thus producing numerous inducible B cells and tolerant B cells, whose dysfunction can easily result in inflammatory bowel disease (IBD). Also, the disorder of humoral immune function mediated by memory B cells has a critical position in the pathogenesis of IBD. As an immune suppressant, curcumin (Cur) has a therapeutic role in treating many immune diseases, such as IBD and rheumatoid arthritis. Meanwhile, it has proven efficacy in experimental colitis mice and patients with ulcerative colitis (UC), while the disturbances in memory B cells have been observed in IBD. However, few studies have explored whether Cur treatment of colitis is closely related to memory B cells. In the present research, our results indicated that Cur effectively alleviated DSS-induced UC in mice via a potential mechanism involving memory B cells and the Bcl-6-Syk-BLNK signaling pathway. |
| Publish Date |
2022-10-28 12:37 |
| Citation |
Wei SY, Wu TT, Huang JQ, Kang ZP, Wang MX, Zhong YB, Ge W, Zhou BG, Zhao HM, Wang HY, Liu DY. Curcumin alleviates experimental colitis via a potential mechanism involving memory B cells and Bcl-6-Syk-BLNK signaling. World J Gastroenterol 2022; 28(40): 5865-5880 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i40/5865.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i40.5865 |
