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Articles Published Processes
12/12/2022 6:36:34 AM | Browse: 406 | Download: 1475
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Received |
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2022-07-10 06:37 |
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Peer-Review Started |
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2022-07-10 06:40 |
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First Decision by Editorial Office Director |
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2022-09-26 07:50 |
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Return for Revision |
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2022-09-28 14:42 |
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Revised |
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2022-10-16 18:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-11-21 03:29 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-11-22 02:40 |
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Articles in Press |
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2022-11-22 02:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-12-05 03:43 |
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Publish the Manuscript Online |
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2022-12-12 06:36 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhao-Hua Shen, Wei-Wei Luo, Xing-Cong Ren, Xiao-Yan Wang and Jin-Ming Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Changsha Municipal Natural Science Foundation |
No. kq2014258 |
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| Corresponding Author |
Jin-Ming Yang, Doctor, Academic Editor, Department of Cancer Biology and Toxicology, University of Kentucky College of Medicine, 101 Main Building Lexington, Lexington, MA 40506, United States. yangjinming285@sina.com |
| Key Words |
Nucleus accumbens-1; Colon cancer; Tumor immunity; Programmed death receptor-1/programmed death receptor-1 ligand; CD8+ T cells |
| Core Tip |
We determined whether and how nucleus accumbens-1 (NAC-1) affects antitumor immunity in colon cancer. Knockdown of NAC-1 expression in colon cancer cells significantly enhanced the cytocidal effect of CD8+ T cells. Knockdown of NAC-1 in colon cancer cells decreased the expression of programmed death receptor-1 ligand. Depletion of tumoral NAC-1 increased the amount of CD8+ T cells but decreased the amount of suppressive myeloid-derived suppressor cells and regulatory T cells. It comes to a conclusion that tumoral expression of NAC-1 is a negative determinant of immunotherapy. |
| Publish Date |
2022-12-12 06:36 |
| Citation |
Shen ZH, Luo WW, Ren XC, Wang XY, Yang JM. Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity. World J Gastrointest Oncol 2022; 14(12): 2329-2339
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| URL |
https://www.wjgnet.com/1948-5204/full/v14/i12/2329.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i12.2329 |
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