Publication Name	World Journal of Gastroenterology
Manuscript ID	7885
Country	China

Received	2013-12-05 08:09
Peer-Review Started	2013-12-05 09:07
To Make the First Decision	2014-01-15 17:00
Return for Revision	2014-01-20 18:15
Revised	2014-02-08 04:16
Second Decision	2014-04-03 10:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 11:22
Articles in Press	2014-05-23 10:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-30 07:01
Typeset the Manuscript	2014-07-15 13:28
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Autobiography
Article Title	Viral infection parameters not nucleoside analogue itself correlates with host immunity in nucleoside analogue therapy for chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	Cheng-Zhong Li, Jing-Jing Hu, Jian-Ya Xue, Wei Yin, Ya-Yun Liu, Wen-Han Fan, Hao Xu and Xue-Song Liang
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Natural Science Fund 09ZR1400500 National Natural Science Foundation of China 30972600 GuangHui Fund of Hepatitis Prevention Fund Committee China GHZ20100204 Shanghai Health Bureau Fund 2012092
Corresponding Author	Xue-Song Liang, Associate Professor, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. liangxuesong2000@163.com
Key Words	Chronic hepatitis B; Nucleoside analogues; Immune modulation; Programmed death-1; CD4+ CD25+ FoxP3+ T regulatory cells
Core Tip	We compared the host immunity of hepatitis B envelope antigen (HBeAg)-positive patients treated with telbivudine (LDT) to those treated with lamivudine (LAM) and longitudinally investigated the relationship between two important negative immune modulating factors and viral infection parameters in HBeAg-positive chronic hepatitis B (CHB) patients that were treated with the nucleoside analogues (NAs) LDT and LAM. NA-mediated inhibition of hepatitis B virus replication could cause the downregulation of PD-1+ CD8 T cells and Treg cells during the first 24 wk of therapy and could also partially restore the ability of CD8 T cells to secrete pro-inflammatory cytokines. The immune modulating effect associated with NA treatment in CHB patients was correlated with the levels of both HBV DNA and HBeAg.
Publish Date	2014-07-26 13:36
Citation	Li CZ, Hu JJ, Xue JY, Yin W, Liu YY, Fan WH, Xu H, Liang XS. Viral infection parameters not nucleoside analogue itself correlates with host immunity in nucleoside analogue therapy for chronic hepatitis B. World J Gastroenterol 2014; 20(28): 9486-9496
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9486.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9486

Full Article (PDF)	WJG-20-9486.pdf
Full Article (Word)	WJG-20-9486.doc
Manuscript File	7885-Review.docx
Answering Reviewers	7885-Answering reviewers.pdf
Copyright License Agreement	7885-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131204103218.jpg
Non-Native Speakers of English Editing Certificate	7885-Language certificate.pdf
Peer-review Report	7885-Peer reviw(s).pdf
Scientific Editor Work List	7885-Scientific editor work list.doc