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8/25/2014 4:06:00 PM | Browse: 769 | Download: 910
Publication Name World Journal of Gastroenterology
Manuscript ID 7885
Country/Territory China
Received
2013-12-05 08:09
Peer-Review Started
2013-12-05 09:07
To Make the First Decision
2014-01-15 17:00
Return for Revision
2014-01-20 18:15
Revised
2014-02-08 04:16
Second Decision
2014-04-03 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-03 11:22
Articles in Press
2014-05-23 10:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-04-30 07:01
Typeset the Manuscript
2014-07-15 13:28
Publish the Manuscript Online
2014-07-26 13:36
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Autobiography
Article Title Viral infection parameters not nucleoside analogue itself correlates with host immunity in nucleoside analogue therapy for chronic hepatitis B
Manuscript Source Invited Manuscript
All Author List Cheng-Zhong Li, Jing-Jing Hu, Jian-Ya Xue, Wei Yin, Ya-Yun Liu, Wen-Han Fan, Hao Xu and Xue-Song Liang
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Natural Science Fund 09ZR1400500
National Natural Science Foundation of China 30972600
GuangHui Fund of Hepatitis Prevention Fund Committee China GHZ20100204
Shanghai Health Bureau Fund 2012092
Corresponding Author Xue-Song Liang, Associate Professor, Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. liangxuesong2000@163.com
Key Words Chronic hepatitis B; Nucleoside analogues; Immune modulation; Programmed death-1; CD4+ CD25+ FoxP3+ T regulatory cells
Core Tip We compared the host immunity of hepatitis B envelope antigen (HBeAg)-positive patients treated with telbivudine (LDT) to those treated with lamivudine (LAM) and longitudinally investigated the relationship between two important negative immune modulating factors and viral infection parameters in HBeAg-positive chronic hepatitis B (CHB) patients that were treated with the nucleoside analogues (NAs) LDT and LAM. NA-mediated inhibition of hepatitis B virus replication could cause the downregulation of PD-1+ CD8 T cells and Treg cells during the first 24 wk of therapy and could also partially restore the ability of CD8 T cells to secrete pro-inflammatory cytokines. The immune modulating effect associated with NA treatment in CHB patients was correlated with the levels of both HBV DNA and HBeAg.
Publish Date 2014-07-26 13:36
Citation Li CZ, Hu JJ, Xue JY, Yin W, Liu YY, Fan WH, Xu H, Liang XS. Viral infection parameters not nucleoside analogue itself correlates with host immunity in nucleoside analogue therapy for chronic hepatitis B. World J Gastroenterol 2014; 20(28): 9486-9496
URL http://www.wjgnet.com/1007-9327/full/v20/i28/9486.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i28.9486
Full Article (PDF) WJG-20-9486.pdf
Full Article (Word) WJG-20-9486.doc
Manuscript File 7885-Review.docx
Answering Reviewers 7885-Answering reviewers.pdf
Copyright License Agreement 7885-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20131204103218.jpg
Non-Native Speakers of English Editing Certificate 7885-Language certificate.pdf
Peer-review Report 7885-Peer reviw(s).pdf
Scientific Editor Work List 7885-Scientific editor work list.doc