Publication Name	World Journal of Clinical Cases
Manuscript ID	78885
Country	China

Received	2022-07-20 05:13
Peer-Review Started	2022-07-20 05:15
First Decision by Editorial Office Director	2022-11-05 07:50
Return for Revision	2022-11-08 05:48
Revised	2022-11-20 12:11
Publication Fee Transferred
Second Decision by Editor	2022-12-07 03:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-12-08 00:19
Articles in Press	2022-12-08 00:19
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-13 03:11
Publish the Manuscript Online	2022-12-26 18:23

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable
Manuscript Source	Invited Manuscript
All Author List	Feng-Ju Jia and Jing Han
ORCID	Author(s) ORCID Number Feng-Ju Jia http://orcid.org/0000-0002-5406-913X
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Provincial Natural Science Foundation ZR2020QC088
Corresponding Author	Feng-Ju Jia, PhD, Doctor, Doctor, School of Nursing, Qingdao University, No. 308 Ningxia Road, Qingdao 266071, Shandong Province, China. jiafegngjv@163.com
Key Words	COVID-19; Liver injury; Ferritinophagy; Ferroptosis; Iron; SARS-CoV-2
Core Tip	Liver injury in patients with coronavirus disease 2019 (COVID-19) has progressively emerged, yet the exact pathophysiological mechanisms to explain liver pathogenicity is presently not fully understood. We hypothesize that cytokine storms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may promote hyper-ferritinemia, which can further aggravate inflammation. Elevated ferritin levels can trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, which leads to iron elevation, and ferroptosis. NCOA4-mediated ferritinophagy can be targeted to limit the ferroptosis and, therefore, prevent liver damage and disease severity in patients with COVID-19.
Publish Date	2022-12-26 18:23
Citation	Jia FJ, Han J. Liver injury in COVID-19: Holds ferritinophagy-mediated ferroptosis accountable. World J Clin Cases 2022; 10(36): 13148-13156
URL	https://www.wjgnet.com/2307-8960/full/v10/i36/13148.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i36.13148

Full Article (PDF)	WJCC-10-13148.pdf
Full Article (Word)	WJCC-10-13148.docx
Manuscript File	78885_Auto_Edited-LJH-JLW.docx
Answering Reviewers	78885-Answering reviewers.pdf
Audio Core Tip	78885-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	78885-Conflict-of-interest statement.pdf
Copyright License Agreement	78885-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	78885-Language certificate.pdf
Supplementary Material	78885-Supplementary material.pdf
Peer-review Report	78885-Peer-review(s).pdf
Scientific Misconduct Check	78885-Bing-Liu JH-2.jpg
Scientific Misconduct Check	78885-CrossCheck.jpg
Scientific Editor Work List	78885-Scientific editor work list.pdf
CrossCheck Report	78885-CrossCheck report.pdf