Publication Name	World Journal of Clinical Cases
Manuscript ID	79175
Country	China

Received	2022-08-08 07:27
Peer-Review Started	2022-08-08 07:30
To Make the First Decision
Return for Revision	2022-09-05 10:16
Revised	2022-09-15 01:52
Second Decision	2022-09-23 03:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-23 08:51
Articles in Press	2022-09-23 08:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-17 13:46
Publish the Manuscript Online	2022-10-27 04:55

ISSN	2307-8960 (online)
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Category	Infectious Diseases
Manuscript Type	Meta-Analysis
Article Title	Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Jiang-Lin Wang, Bi-Xiao Xiang, Xiao-Li Song, Rui-Man Que, Xiao-Cong Zuo and Yue-Liang Xie
ORCID	Author(s) ORCID Number Jiang-Lin Wang http://orcid.org/0000-0003-4243-9663 Yue-Liang Xie http://orcid.org/0000-00002-6178-8722
Funding Agency and Grant Number	Funding Agency Grant Number the Scientific Project of Hunan Provincial Science and Technology Department B20180896 Nature Science Foundation of Changsha NO. kq2014268 Hunan Engineering Research Center of Intelligent Prevention and Control for Drug Induced Organ Injury NO.40 Scientific Research Fund project of Hunan Pharmaceutical Society NO.2020YXH010
Corresponding Author	Yue-Liang Xie, PharmD, Pharmacist, Department of Pharmacy, The Third Xiangya Hospital of Central South University, No. 138 Tongzipo Road , Changsha 410013, Hunan Province, China. xieyliang@csu.edu.cn
Key Words	Polymyxins; Nephrotoxicity; Critically ill adult patients; Risk factors; Meta-analysis
Core Tip	Polymyxins have recently been reintroduced as a last-line option in chemotherapy for infections caused by multidrug-resistant gram-negative bacteria. However, these agents can cause nephrotoxicity. Notably, the prevalence of and risk factors for polymyxin-associated nephrotoxicity in adult intensive care unit (ICU) patients remain unclear. This is the first systematic review and meta-analysis to estimate the prevalence of and risk factors for polymyxin-induced nephrotoxicity in adult ICU patients. Based on the data collected and analysed, we conclude that the high incidence of polymyxin-induced nephrotoxicity is a primary safety concern and challenge in clinical practice. The avoidance of modifiable risk factors (such as nephrotoxic drugs and dosage regimens containing polymyxins) in adult ICU patients can likely reduce the risk of polymyxin-induced nephrotoxicity.
Publish Date	2022-10-27 04:55
Citation	Wang JL, Xiang BX, Song XL, Que RM, Zuo XC, Xie YL. Prevalence of polymyxin-induced nephrotoxicity and its predictors in critically ill adult patients: A meta-analysis. World J Clin Cases 2022; 10(31): 11466-11485
URL	https://www.wjgnet.com/2307-8960/full/v10/i31/11466.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i31.11466

Full Article (PDF)	WJCC-10-11466.pdf
Full Article (Word)	WJCC-10-11466.docx
Manuscript File	79175_Auto_Edited-LJH-JLW.docx
Answering Reviewers	79175-Answering reviewers.pdf
Audio Core Tip	79175-Audio core tip.m4a
Biostatistics Review Certificate	79175-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79175-Conflict-of-interest statement.pdf
Copyright License Agreement	79175-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79175-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	79175-Language certificate.pdf
Supplementary Material	79175-Supplementary material.pdf
Peer-review Report	79175-Peer-review(s).pdf
Scientific Misconduct Check	79175-Bing-Liu JH-2.jpg
Scientific Misconduct Check	79175-CrossCheck.jpg
Scientific Editor Work List	79175-Scientific editor work list.pdf
CrossCheck Report	79175-CrossCheck report.pdf