Publication Name	World Journal of Gastroenterology
Manuscript ID	7926
Country	United States

Received	2013-12-06 21:56
Peer-Review Started	2013-12-08 14:00
To Make the First Decision	2013-12-26 11:34
Return for Revision	2013-12-27 15:59
Revised	2014-01-07 15:54
Second Decision	2014-03-05 15:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 15:35
Articles in Press	2014-05-23 11:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-27 17:21
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice
Manuscript Source	Invited Manuscript
All Author List	Hanying Zhang, Yansong Xue, Hui Wang, Yan Huang, Min Du, Qiyuan Yang and Mei-Jun Zhu
Funding Agency and Grant Number	Funding Agency Grant Number USDA-AFRI 2009-65203-05716 NIH 1R15HD073864 NIH-INBRE P20RR016474
Corresponding Author	Dr. Mei-Jun Zhu, School of Food Science, Washington State University, Pullman, WA 99164, United States. meijun.zhu@wsu.edu
Key Words	Colitis; Interleukin-10; Inflammation; Inflammatory bowel disease; Mast cells; Mice
Core Tip	Colitis is characterized by chronic inflammation and mast cells accumulate at the pathological sites, implicating their mediating roles, but the exact roles of mast cells in colitis remain poorly defined and controversial. In this study, the authors cross-bred mast cell-deficient mice with interleukin-10-deficient mice to investigate the role of mast cells in gut inflammation and the onset of colitis. Data show that mast cells have protective roles in the development of colitis by suppressing Th1 type immune response and inflammation, altering gut microbiota composition, improving gut epithelial barrier function, and reducing epithelial damage.
Publish Date	2014-07-21 17:17
Citation	Zhang H, Xue Y, Wang H, Huang Y, Du M, Yang Q, Zhu MJ. Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice. World J Gastroenterol 2014; 20(27): 9106-9115
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/9106.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.9106

Full Article (PDF)	WJG-20-9106.pdf
Full Article (Word)	WJG-20-9106.doc
Manuscript File	7926-Review.docx
Answering Reviewers	7926-Answering reviewers.pdf
Copyright License Agreement	7926-Copyright assignment.pdf
Peer-review Report	7926-Peer review(s).pdf
Scientific Editor Work List	7926-Scientific editor work list.doc