| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Survival benefit of younger gastric cancer patients in China than the United States: A comparative study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Hui Niu, Lu-Lu Zhao, Wan-Qing Wang, Xiao-Jie Zhang, Ze-Feng Li, Xiao-Yi Luan and Ying-Tai Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2017YFC0908300 |
|
| Corresponding Author |
Ying-Tai Chen, MD, N/A, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing 100021, China. yingtaichen@126.com |
| Key Words |
Gastric cancer; Younger patients; Racial disparity; Regional disparity; Prediction model; Biological analysis |
| Core Tip |
The impact of racial and regional disparity on younger patients with gastric cancer (GC) was not clear. A total of 6098 younger GC patients were selected from 2000 to 2018, of which 1159 were enrolled in China National Cancer Center, 4939 were collected from Surveillance Epidemiology and End Results database. Compare with the United States group, younger patients in China revealed better survival outcomes. For race/ethnicity, younger Chinese cases also enjoyed a better prognosis than that in White and Black sets. Later, prognostic nomograms for younger patients were established, with the area under the curve 0.786 in China group and 0.842 in the United States group. Moreover, three gene expression profiles (GSE27342, GSE51105, and GSE38749) from Gene Expression Omnibus database were enrolled in further biological analysis, and distinctive molecular characteristics were identified in younger GC patients among different regions. |
| Publish Date |
2023-02-10 09:15 |
| Citation |
Niu PH, Zhao LL, Wang WQ, Zhang XJ, Li ZF, Luan XY, Chen YT. Survival benefit of younger gastric cancer patients in China than the United States: A comparative study. World J Gastroenterol 2023; 29(6): 1090-1108 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i6/1090.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i6.1090 |
