| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
COVID-19 and liver injury: An ongoing challenge
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ioanna Papagiouvanni, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, Dionisios G Spyratos, Konstantinos Porpodis, Afroditi K Boutou, Georgios Papagiouvannis, Ioanna Grigoriou, Christos Vettas and Ioannis Goulis |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ioanna Papagiouvanni, MSc, Doctor, Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, 49 Konstantinoupoleos, Thessaloniki 54642, Thessaloniki, Greece. ioanna.d.pap@gmail.com |
| Key Words |
COVID-19; Liver injury; Cytokine storm; Hypoxic hepatitis; Drug-induced liver injury; Chronic liver disease |
| Core Tip |
Liver injury is a common feature in coronavirus disease 2019 (COVID-19) patients and was associated with disease severity and prognosis. Multiple pathophysiological mechanisms are responsible for liver injury, including direct viral effect, cytokine storm, hypoxia and drug hepatotoxicity, however, further research is needed, in order, for them, to be clearly defined. Patients with underlying chronic liver disease may be more susceptible to severe acute respiratory syndrome coronavirus 2 infection; nevertheless, evidence is still limited. It is necessary to know the mechanisms of liver injury, the clinical manifestations and the effect of COVID-19 in underlying liver disease, in order to design appropriate management programs. |
| Publish Date |
2023-01-06 02:52 |
| Citation |
Papagiouvanni I, Kotoulas SC, Pataka A, Spyratos DG, Porpodis K, Boutou AK, Papagiouvannis G, Grigoriou I, Vettas C, Goulis I. COVID-19 and liver injury: An ongoing challenge. World J Gastroenterol 2023; 29(2): 257-271 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i2/257.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i2.257 |
