Publication Name	World Journal of Gastroenterology
Manuscript ID	80158
Country	Romania

Received	2022-09-18 20:18
Peer-Review Started	2022-09-18 20:20
To Make the First Decision
Return for Revision	2022-10-19 03:22
Revised	2022-11-06 19:59
Second Decision	2022-12-20 08:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-21 02:52
Articles in Press	2022-12-21 02:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-12-01 22:22
Typeset the Manuscript	2022-12-28 07:10
Publish the Manuscript Online	2023-01-06 02:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Simona Cernea and Danusia Onișor
ORCID	Author(s) ORCID Number Simona Cernea http://orcid.org/0000-0002-9494-6571 Danusia Onișor http://orcid.org/0000-0002-5710-9109
Funding Agency and Grant Number
Corresponding Author	Simona Cernea, MD, PhD, Associate Professor, Department M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 38 Gheorghe Marinescu st., Târgu Mureş 540139, Romania. simonacernea@yahoo.com
Key Words	Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Hepatocellular carcinoma; Risk stratification; Lifestyle interventions; Prevention
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is a public health problem, especially in developed countries. This condition, depending on certain associated risk factors, can ultimately lead to liver cirrhosis and hepatocellular carcinoma (HCC). Having the necessary tools and knowing the characteristics of patients in whom the disease progresses more quickly, effective monitoring programs can be developed. Primary prevention of NAFLD/nonalcoholic steatohepatitis (NASH)-associated HCC relies on controlling the main modifiable risk factors. Some pharmacological (e.g., metformin, statins, aspirin) and non-pharmacological interventions (weight loss, physical exercise, healthy diet, avoiding heavy drinking and smoking) might have protective effects. Herein, we emphasized the need for continued investigations to find the optimal methods for NAFLD/NASH-associated prevention.
Publish Date	2023-01-06 02:52
Citation	Cernea S, Onișor D. Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma. World J Gastroenterol 2023; 29(2): 286-309
URL	https://www.wjgnet.com/1007-9327/full/v29/i2/286.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i2.286

Full Article (PDF)	WJG-29-286.pdf
Full Article (Word)	WJG-29-286.docx
Manuscript File	80158_Auto_Edited-JLW-Filipodia-JLW.docx
Answering Reviewers	80158-Answering reviewers.pdf
Audio Core Tip	80158-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80158-Conflict-of-interest statement.pdf
Copyright License Agreement	80158-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80158-Language certificate.pdf
Peer-review Report	80158-Peer-review(s).pdf
Scientific Editor Work List	80158-Scientific editor work list.pdf
CrossCheck Report	80158-CrossCheck report.pdf