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Articles Published Processes
12/21/2022 3:07:33 AM | Browse: 240 | Download: 774
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Received |
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2022-09-27 08:50 |
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Peer-Review Started |
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2022-09-27 08:52 |
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To Make the First Decision |
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Return for Revision |
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2022-10-10 00:25 |
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Revised |
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2022-10-30 09:44 |
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Second Decision |
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2022-12-01 07:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-12-07 18:45 |
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Articles in Press |
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2022-12-07 18:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-12-16 09:19 |
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Publish the Manuscript Online |
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2022-12-21 03:07 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Optimal concentration of mesenchymal stem cells for fracture healing in a rat model with long bone fracture
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Myung-Seo Kim, Hyun-Ju Chung and Kang-Il Kim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Health Technology R&D Project |
HI20C1405 |
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| Corresponding Author |
Kang-Il Kim, MD, PhD, Professor, Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University and Kyung Hee University Hospital at Gangdong, 892, Dongnam-ro, Gangdong-gu, Seoul 05278, South Korea. khuknee@gmail.com |
| Key Words |
Rat model; Femoral shaft fracture; Mesenchymal stem cells; Direct injection; Optimal concentration; Fracture healing |
| Core Tip |
This study focused on the optimal concentration of mesenchymal stem cells (MSCs) that affect fracture healing in a rat model of long bone shaft fracture. Factors related to the homing effect of MSCs, osteogenesis and angiogenesis were analyzed by in vivo (radiographic and histologic evaluation) as well as in vitro (reverse transcriptase-polymerase chain reaction and western blot analysis). Among the various concentrations used, the administration of at least 5.0 × 106 MSCs was optimal to promote the therapeutic effect on fracture healing. |
| Publish Date |
2022-12-21 03:07 |
| Citation |
Kim MS, Chung HJ, Kim KI. Optimal concentration of mesenchymal stem cells for fracture healing in a rat model with long bone fracture. World J Stem Cells 2022; 14(12): 839-850 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i12/839.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i12.839 |
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