Publication Name	World Journal of Gastroenterology
Manuscript ID	80300
Country	Nigeria

Received	2022-09-22 14:38
Peer-Review Started	2022-09-22 14:40
To Make the First Decision
Return for Revision	2022-10-18 17:11
Revised	2022-11-02 20:45
Second Decision	2022-12-20 08:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-12-21 03:13
Articles in Press	2022-12-21 03:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-12-30 05:59
Publish the Manuscript Online	2023-01-06 02:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Modern drug discovery for inflammatory bowel disease: The role of computational methods
Manuscript Source	Invited Manuscript
All Author List	Titilayo Omolara Johnson, Augustina Oduje Akinsanmi, Stephen Adakole Ejembi, Olugbenga Eyitayo Adeyemi, Jane-Rose Oche, Grace Inioluwa Johnson and Abayomi Emmanuel Adegboyega
ORCID	Author(s) ORCID Number Titilayo Omolara Johnson http://orcid.org/0000-0002-4230-8025
Funding Agency and Grant Number
Corresponding Author	Titilayo Omolara Johnson, BSc, MSc, PhD, Associate Professor, Biochemistry, University of Jos, Bauchi road, Jos 930222, Plateau, Nigeria. titijohnson2004@yahoo.com
Key Words	Inflammatory bowel disease; Computer-aided drug design; Janus Kinase; Molecular docking; Genome-wide association study; Molecular dynamics simulation
Core Tip	For the design of small molecule drugs to treat inflammatory bowel disease (IBD), highly effective and time-saving approaches, such as computational methods, are still a viable choice. By complementing experimental studies with computational approaches, the probability of successful drug discovery is increased while simultaneously reducing associated costs. This article provides a summary of the current drug discovery pipeline for IBD, with special emphasis on the part played by computational methods. The use of in silico genomic studies, target identification, and virtual screening to find new drugs and repurpose existing drugs for the treatment of IBD are discussed.
Publish Date	2023-01-06 02:52
Citation	Johnson TO, Akinsanmi AO, Ejembi SA, Adeyemi OE, Oche JR, Johnson GI, Adegboyega AE. Modern drug discovery for inflammatory bowel disease: The role of computational methods. World J Gastroenterol 2023; 29(2): 310-331
URL	https://www.wjgnet.com/1007-9327/full/v29/i2/310.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i2.310

Full Article (PDF)	WJG-29-310.pdf
Full Article (Word)	WJG-29-310.docx
Manuscript File	80300_Auto_Edited-JLW.docx
Answering Reviewers	80300-Answering reviewers.pdf
Audio Core Tip	80300-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80300-Conflict-of-interest statement.pdf
Copyright License Agreement	80300-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80300-Language certificate.pdf
Peer-review Report	80300-Peer-review(s).pdf
Scientific Misconduct Check	80300-Bing-Liu GL-2.png
Scientific Editor Work List	80300-Scientific editor work list.pdf
CrossCheck Report	80300-CrossCheck report.pdf