Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	80475
Country	China

Received	2022-09-30 00:51
Peer-Review Started	2022-09-30 00:54
To Make the First Decision
Return for Revision	2023-01-05 15:15
Revised	2023-01-29 16:24
Second Decision	2023-04-07 01:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-07 03:46
Articles in Press	2023-04-07 03:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-02 06:00
Publish the Manuscript Online	2023-06-15 12:09

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Retrospective Study
Article Title	Long-term outcomes and failure patterns after laparoscopic intersphincteric resection in ultralow rectal cancers
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Long Qiu, Xiao-Lin Wang, Jun-Guang Liu, Gang Hu, Shi-Wen Mei and Jian­-Qiang Tang
ORCID	Author(s) ORCID Number Wen-Long Qiu http://orcid.org/0000-0002-6938-7878 Shi-Wen Mei http://orcid.org/0000-0002-9735-3261 Jian­-Qiang Tang http://orcid.org/0000-0003-3933-8060
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81272710 Beijing Nature Fund 4232058 Beijing Natural Fund Haidian Special L222054
Corresponding Author	Jian­-Qiang Tang, MD, PhD, Chief Doctor, Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. doc_tjq@hotmail.com
Key Words	Rectal cancer; Intersphincteric resection; Laparoscopic surgery; Recurrence; Risk factors
Core Tip	We aimed to investigate the failure patterns and risk factors for local recurrence and distant metastasis in 368 patients who underwent iaparoscopic Intersphincteric resection (LsISR). Local recurrence and distant metastasis occurred in 13 (3.5%) and 42 (11.4%) patients, respectively. The 3-year overall survival, local recurrence-free survival, and distant metastasis-free survival rates were 91.3%, 97.1%, and 90.1%, respectively. Multivariate analyses revealed that LRFS was associated with positive lymph node status and poor differentiation, whereas the independent prognostic factors for DMFS were positive lymph node status and (y)pT3 stage. We believe that our study makes a significant contribution to the literature because it confirmed the oncological safety of LsISR for ultralow rectal cancer. This paper will be of interest to the readership of your journal because it demonstrated that poor differentiation, (y)pT3 stage, and lymph node metastasis are independent risk factors for treatment failure after LsISR, and thus patients with these factors should be carefully managed with optimal neoadjuvant therapy and surgical strategy.
Publish Date	2023-06-15 12:09
Citation	Qiu WL, Wang XL, Liu JG, Hu G, Mei SW, Tang JQ. Long-term outcomes and failure patterns after laparoscopic intersphincteric resection in ultralow rectal cancers. World J Gastrointest Surg 2023; 15(6): 1104-1115
URL	https://www.wjgnet.com/1948-9366/full/v15/i6/1104.htm
DOI	https://dx.doi.org/10.4240/wjgs.v15.i6.1104

Full Article (PDF)	WJGS-15-1104-with-cover.pdf
Full Article (Word)	WJGS-15-1104.docx
Manuscript File	80475_Auto_Edited-JLW.docx
Answering Reviewers	80475-Answering reviewers.pdf
Audio Core Tip	80475-Audio core tip.m4a
Biostatistics Review Certificate	80475-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	80475-Conflict-of-interest statement.pdf
Copyright License Agreement	80475-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80475-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	80475-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	80475-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	80475-Language certificate.pdf
Scientific Misconduct Check	80475-Bing-Liu GL-2.png
Scientific Editor Work List	80475-Scientific editor work list.pdf
CrossCheck Report	80475-CrossCheck report.pdf
CrossCheck Report	80475-Peer-review(s).pdf