Publication Name	World Journal of Gastroenterology
Manuscript ID	80502
Country	India

Received	2022-09-29 16:19
Peer-Review Started	2022-09-29 16:20
To Make the First Decision
Return for Revision	2022-12-12 08:16
Revised	2022-12-23 06:26
Second Decision	2023-01-20 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-01-20 23:48
Articles in Press	2023-01-20 23:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-27 17:59
Typeset the Manuscript	2023-01-30 07:07
Publish the Manuscript Online	2023-02-10 09:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immunotherapy for hepatocellular carcinoma: Current status and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Deepa S Mandlik, Satish K Mandlik and Heena B Choudhary
ORCID	Author(s) ORCID Number Deepa S Mandlik http://orcid.org/0000-0001-8505-7038
Funding Agency and Grant Number
Corresponding Author	Deepa S Mandlik, PhD, Assistant Professor, Department of Pharmacology, BVDU, Poona College of Pharmacy, Kothrud, Pune 411038, Maharashtra, India. deepa.mandlik@bharatividyapeeth.edu
Key Words	Hepatocellular carcinoma; Immunotherapy; Immune checkpoint inhibitors; Alpha-fetoprotein; Cancer vaccine; Combination therapies
Core Tip	Core Tip: Hepatocellular carcinoma (HCC) is a multifaceted illness with multiple faces. It avoids early discovery, which provides the best chance of cure by resection/transplant, and systemic treatments are only of marginal efficacy at best, despite recent therapeutic advances. Current advances in immunotherapy and its combinations have altered the HCC treatment landscape, and clinical studies are continuing to pave the path forward. Immunotherapy increases survival rates and provides long-term cancer control in subsets of HCC patients while also minimising side effects. Further research into immunotherapy in combination with current treatments for HCC in the early and intermediate stages may assist a greater spectrum of patients. Continued research into programmed cell death 1/ programmed cell death ligand 1, TMB, ctDNA, microsatellite stability, DNA mismatch repair, neutrophil/lymphocyte ratio, cytokines, and cellular peripheral immune response will hopefully identify the most reliable marker for selecting and sequencing systemic treatments to achieve the best outcome in HCC patients. Despite such significant treatment advances in HCC, numerous hurdles remain. The scientific community must figure out how to appropriately sequence these medicines for the best potential response, how to control toxicities, and how to develop indicators to monitor for response and relapse.
Publish Date	2023-02-10 09:15
Citation	Mandlik DS, Mandlik SK, Choudhary HB. Immunotherapy for hepatocellular carcinoma: Current status and future perspectives. World J Gastroenterol 2023; 29(6): 1054-1075
URL	https://www.wjgnet.com/1007-9327/full/v29/i6/1054.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i6.1054

Full Article (PDF)	WJG-29-1054.pdf
Full Article (Word)	WJG-29-1054.docx
Manuscript File	80502-Review-Filipodia.docx
Answering Reviewers	80502-Answering reviewers.pdf
Audio Core Tip	80502-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	80502-Conflict-of-interest statement.pdf
Copyright License Agreement	80502-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80502-Language certificate.pdf
Peer-review Report	80502-Peer-review(s).pdf
Scientific Misconduct Check	80502-Bing-Chen YL-2.png
Scientific Editor Work List	80502-Scientific editor work list.pdf