Publication Name	World Journal of Gastroenterology
Manuscript ID	8051
Country	Japan

Received	2013-12-12 17:40
Peer-Review Started	2013-12-13 09:14
To Make the First Decision	2014-02-28 18:23
Return for Revision	2014-03-07 18:43
Revised	2014-03-27 09:34
Second Decision	2014-06-05 10:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-05 10:59
Articles in Press	2014-06-05 11:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-12 14:43
Typeset the Manuscript	2014-11-24 11:04
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Observational Study
Article Title	Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Masafumi Inoue, Yoshihisa Takahashi, Takeshi Fujii, Masanobu Kitagawa and Toshio Fukusato
Funding Agency and Grant Number
Corresponding Author	Yoshihisa Takahashi, MD, Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. ytakaha-tky@umin.ac.jp
Key Words	Liver fatty acid-binding protein; Hepatocellular carcinoma; Hepatocellular adenoma; Immunohistochemical staining; β-catenin
Core Tip	The significance of the downregulation of liver fatty acid-binding protein (L-FABP) expression in hepatocellular carcinoma (HCC) is largely unknown. In the present study, we performed immunohistochemical staining for L-FABP in 146 cases of HCC. We found that, in smaller HCC, L-FABP downregulation occurs, probably because of phenotypic changes during tumor progression. Moreover, L-FABP downregulation correlated with tumor differentiation and intratumor inflammation.
Publish Date	2014-12-18 17:08
Citation	Inoue M, Takahashi Y, Fujii T, Kitagawa M, Fukusato T. Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma. World J Gastroenterol 2014; 20(46): 17541-17551
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17541.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17541

Full Article (PDF)	WJG-20-17541.pdf
Full Article (Word)	WJG-20-17541.doc
Manuscript File	8051-Review.docx
Answering Reviewers	8051-Answering reviewers.pdf
Copyright License Agreement	8051-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8051-Language certificate.pdf
Peer-review Report	8051-Peer review(s).pdf
Scientific Misconduct Check	8051-CrossCheck.jpg
Scientific Editor Work List	8051-Scientific editor work list.pdf