Publication Name	World Journal of Gastroenterology
Manuscript ID	8056
Country	Türkiye

Received	2013-12-14 16:16
Peer-Review Started	2013-12-15 09:34
To Make the First Decision	2014-01-15 13:23
Return for Revision	2014-01-20 18:46
Revised	2014-02-17 01:57
Second Decision	2014-04-03 10:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 11:31
Articles in Press	2014-05-23 09:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-19 15:37
Publish the Manuscript Online	2014-07-03 15:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Levent Doganay, Arta Fejzullahu, Seyma Katrinli, Feruze Yilmaz Enc, Oguzhan Ozturk, Yasar Colak, Celal Ulasoglu, Ilyas Tuncer and Gizem Dinler Doganay
Funding Agency and Grant Number	Funding Agency Grant Number Internal research funds of Istanbul Technical University 36403
Corresponding Author	Gizem Dinler Doganay, PhD, Associate Professor, Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul 34469, Turkey. gddoganay@itu.edu.tr
Key Words	Chronic active hepatitis; Cirrhosis; Hepatitis B; Human leukocyte antigen DQ; Human leukocyte antigen DR
Core Tip	Chronic hepatitis B is a major health problem worldwide. Recent genome-wide association studies revealed a significant association between the human leukocyte antigen (HLA) class Ⅱ region and chronic hepatitis B. In the present study, we genotyped HLA DQB1 and DRB1 alleles in 355 chronic hepatitis B patients and investigated the effects of the HLA alleles on disease activity and cirrhosis development. We found that DQB1*05:01 was a risk factor for chronic active hepatitis and that DRB1*07 was a protective factor against cirrhosis. A bioinformatics analysis revealed that DRB1*07 might be associated with a hypoimmune response.
Publish Date	2014-07-03 15:30
Citation	Doganay L, Fejzullahu A, Katrinli S, Yilmaz Enc F, Ozturk O, Colak Y, Ulasoglu C, Tuncer I, Dinler Doganay G. Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis b. World J Gastroenterol 2014; 20(25): 8179-8186
URL	http://www.wjgnet.com/1007-9327/full/v20/i25/8179.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i25.8179

Full Article (PDF)	WJG-20-8179.pdf
Full Article (Word)	WJG-20-8179.doc
Manuscript File	8056-Review.docx
Answering Reviewers	8056-Answering reviewers.pdf
Copyright License Agreement	8056-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8056-Language certificate.pdf
Peer-review Report	8056-Peer review(s).docx
Scientific Editor Work List	8056-Scientific editor work list.doc