Publication Name	World Journal of Diabetes
Manuscript ID	8059
Country	France

Received	2013-12-14 16:27
Peer-Review Started	2013-12-15 09:46
To Make the First Decision	2014-01-16 08:11
Return for Revision	2014-01-17 13:20
Revised	2014-01-29 22:03
Second Decision	2014-05-08 17:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-08 17:54
Articles in Press	2014-05-23 09:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-13 21:06
Publish the Manuscript Online	2014-06-16 15:44

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	Defect of insulin signal in peripheral tissues: Important role of ceramide
Manuscript Source	Invited Manuscript
All Author List	Rima Hage Hassan, Olivier Bourron and Eric Hajduch
Funding Agency and Grant Number	Funding Agency Grant Number INSERM Société Francophone du Diabète Agence Nationale de la Recherche grant project (Crisalis)
Corresponding Author	Eric Hajduch, Assistant Professor, INSERM, UMR-S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France. eric.hajduch@crc.jussieu.fr
Key Words	Diabetes; Insulin resistance; Lipids; Insulin signaling; Triglycerides; Palmitate; Sphingolipid; Akt; Ceramide synthase; Protein phosphatase 2A; Protein kinase C ?/?
Core Tip	Muscle and liver represent major sites for insulin-mediated glucose metabolism. The ability of insulin to promote its peripheral action is reduced significantly by excess of saturated fat that stimulates intracellular production of second-messenger lipids such as ceramide. Studies suggest that ceramide could be important contributors to lipotoxicity, as the inhibition of early steps its biosynthesis pathway has large beneficial effects in rodent models of obesity and diabetes. In this review, we describe mechanisms by which ceramide acts on insulin-sensitive tissues and we propose that targeting this lipid family could be an interesting approach to fight diabetes.
Publish Date	2014-06-16 15:44
Citation	Hage Hassan R, Bourron O, Hajduch E. Defect of insulin signal in peripheral tissues: Important role of ceramide. World J Diabetes 2014; 5(3): 244-257
URL	http://www.wjgnet.com/1948-9358/full/v5/i3/244.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i3.244

Full Article (PDF)	WJD-5-244.pdf
Full Article (Word)	WJD-5-244.doc
Manuscript File	8059-Review.docx
Answering Reviewers	8059-Answering reviewers.pdf
Copyright License Agreement	8059-Copyright assignment.pdf
Peer-review Report	8059-Peer review(s).pdf
Scientific Editor Work List	8059-Scientific editor work list.pdf