Publication Name	World Journal of Hepatology
Manuscript ID	80959
Country	China

Received	2023-02-05 12:13
Peer-Review Started	2022-10-19 05:25
To Make the First Decision
Return for Revision	2023-03-19 14:39
Revised	2023-03-22 14:30
Second Decision	2023-05-16 03:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-16 10:04
Articles in Press	2023-05-16 10:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-18 13:49
Publish the Manuscript Online	2023-06-25 14:17

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Lower alanine aminotransferase levels are associated with increased all-cause and cardiovascular mortality in nonalcoholic fatty liver patients
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Rui Zheng, Zi-Long Wang, Su-Zhen Jiang, Hong-Song Chen and Bo Feng
ORCID	Author(s) ORCID Number Jia-Rui Zheng http://orcid.org/0000-0003-0202-7488 Zi-Long Wang http://orcid.org/0000-0003-0983-467X Bo Feng http://orcid.org/0000-0001-5084-6715
Funding Agency and Grant Number
Corresponding Author	Bo Feng, MD, PhD, Chief Doctor, Professor, Research Fellow, Peking University Hepatology Institute, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. fengbo@pkuph.edu.cn
Key Words	Non-alcoholic fatty liver disease; Alanine aminotransferase; Mortality; NHANES-III
Core Tip	The risk of nonalcoholic fatty liver disease (NAFLD) was positively correlated with alanine aminotransferase (ALT) level, but all-cause and cardiovascular mortality were the highest when ALT < 0.5 upper limits of normal. Regardless of the severity of NAFLD, normal or lower ALT levels are associated with higher mortality than elevated ALT levels. Clinicians should be aware of not only high ALT, indicating liver injury, but also low ALT associated with higher risk of death.
Publish Date	2023-06-25 14:17
Citation	Zheng JR, Wang ZL, Jiang SZ, Chen HS, Feng B. Lower alanine aminotransferase levels are associated with increased all-cause and cardiovascular mortality in nonalcoholic fatty liver patients. World J Hepatol 2023;15(6): 813-825
URL	https://www.wjgnet.com/1948-5182/full/v15/i6/813.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i6.813

Full Article (PDF)	WJH-15-813-with-cover.pdf
Full Article (Word)	WJH-15-813.docx
Manuscript File	80959_Auto_Edited-JLW.docx
Answering Reviewers	80959-Answering reviewers.pdf
Audio Core Tip	80959-Audio core tip.mp3
Biostatistics Review Certificate	80959-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	80959-Conflict-of-interest statement.pdf
Copyright License Agreement	80959-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	80959-Institutional review board statement.pdf
Supplementary Material	80959-Supplementary material.pdf
Peer-review Report	80959-Peer-review(s).pdf
Scientific Misconduct Check	80959-Bing-Yan JP-2.png
Scientific Editor Work List	80959-Scientific editor work list.pdf