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Articles Published Processes
3/22/2023 11:20:34 AM | Browse: 172 | Download: 511
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Received |
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2022-10-28 02:52 |
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Peer-Review Started |
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2022-10-28 02:54 |
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To Make the First Decision |
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Return for Revision |
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2023-01-04 14:37 |
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Revised |
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2023-01-14 15:01 |
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Second Decision |
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2023-03-17 02:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-03-17 07:30 |
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Articles in Press |
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2023-03-17 07:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-20 00:12 |
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Publish the Manuscript Online |
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2023-03-22 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
COVID-19 and liver dysfunction in children: Current views and new hypotheses
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yang-Fang Yun, Zhi-Yuan Feng and Jing-Jing Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jing-Jing Zhang, Doctor, Professor, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, No. 163 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. jing15209791@nju.edu.cn |
| Key Words |
COVID-19; SARS-CoV-2; Children; Liver injury; Inflammatory immune response; Cytokine storm |
| Core Tip |
There are few cases of liver injury in children with Coronavirus disease 2019 (COVID-19) and clinical reports are scarce. We collected reports on COVID-19-related liver injury (CRLI) in children over the last two years and divided the etiology of CRLI into three categories: (1) the direct mechanism involves severe acute respiratory syndrome coronavirus 2 binding to angiotensin-converting enzyme 2 in the liver or bile duct to exert direct toxicity; (2) the indirect mechanisms include an inflammatory immune response and hypoxia; and (3) COVID-19-related treatments, such as mechanical ventilation and antiviral drugs, may cause liver injury. We also discuss the current controversies regarding the pathophysiology of CRLI. |
| Publish Date |
2023-03-22 11:20 |
| Citation |
Yun YF, Feng ZY, Zhang JJ. COVID-19 and liver dysfunction in children: Current views and new hypotheses. World J Hepatol 2023; 15(3): 353-363 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i3/353.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i3.353 |
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