Publication Name	World Journal of Gastroenterology
Manuscript ID	8106
Country	Italy

Received	2013-12-16 14:12
Peer-Review Started	2013-12-16 15:47
First Decision by Editorial Office Director
Return for Revision	2014-01-20 19:01
Revised	2014-02-09 22:44
Publication Fee Transferred
Second Decision by Editor	2014-05-05 08:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-05 09:50
Articles in Press	2014-05-23 09:44
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-28 11:57
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence-Based Medicine
Article Title	Cost-effectiveness analysis of beta-blockers vs endoscopic surveillance in patients with cirrhosis and small varices
Manuscript Source	Invited Manuscript
All Author List	Lorenza Di Pascoli, Alessandra Buja, Massimo Bolognesi, Sara Montagnese, Angelo Gatta, Dario Gregori and Carlo Merkel
Funding Agency and Grant Number
Corresponding Author	Carlo Merkel, MD, Hepatic Hemodynamic Laboratory and Clinica Medica 5, Department of Medicine, University of Padua, via Giustiniani 2, 35128 Padova, Italy. carlo.merkel@unipd.it
Key Words	Pharmaco-economical analysis; Cirrhosis; Esophageal varices; Variceal bleeding; Primary prophylaxis
Core Tip	In patients with cirrhosis and small esophageal varices no study so far has evaluated the economical consequences of replacing traditional endoscopic surveillance with primary prophylaxis with beta-blockers from this stage. In this study, a decision analysis based on stochastic regression trees and Markov models compared cost-effectiveness of primary prophylaxis with beta-blockers (starting from the diagnosis of small varices) and endoscopic surveillance (and beta-blockers administration when large varices develop). Beta-blocker therapy from the beginning turned out to be more effective and less expensive. This result demonstrate that an early beta-blocker therapy besides being clinically effective, is also also cost-effective.
Publish Date	2014-08-18 16:49
Citation	Di Pascoli L, Buja A, Bolognesi M, Montagnese S, Gatta A, Gregori D, Merkel C. Cost-effectiveness analysis of beta-blockers vs endoscopic surveillance in patients with cirrhosis and small varices. World J Gastroenterol 2014; 20(30): 10464-10469
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10464.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10464

Full Article (PDF)	WJG-20-10464.pdf
Full Article (Word)	WJG-20-10464.doc
Manuscript File	8106-Review.docx
Answering Reviewers	8106-Answering reviewers.pdf
Copyright License Agreement	8106-Copyright assignment.pdf
Peer-review Report	8106-Peer review(s).pdf
Scientific Editor Work List	8106-Scientific editor work list.pdf