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Articles Published Processes
2/14/2023 7:03:17 AM | Browse: 225 | Download: 647
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Received |
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2022-10-27 13:40 |
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Peer-Review Started |
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2022-10-27 13:43 |
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To Make the First Decision |
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Return for Revision |
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2022-11-25 02:21 |
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Revised |
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2022-12-03 09:04 |
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Second Decision |
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2023-01-28 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-01-28 06:10 |
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Articles in Press |
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2023-01-28 06:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-24 13:33 |
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Typeset the Manuscript |
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2023-01-30 09:28 |
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Publish the Manuscript Online |
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2023-02-14 07:03 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Case Report |
| Article Title |
Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Fang Tang, Long-Chuan Xu, Wen-Ting Hong and Hong-Ying Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Ying Shi, PhD, Chief Physician, Department of Immunology, Second Affiliated Hospital of Fujian Medical University, Donghai Street, Fengze District, Quanzhou 362000, Fujian Province, China. shyfly@163.com |
| Key Words |
Tocilizumab; Granulomatosis with polyangiitis; Antineutrophil cytoplasmic antibody; Case report |
| Core Tip |
Granulomatosis with polyangiitis (GPA), formerly called Wegener's granulomatosis, is a necrotizing granulomatous vasculitis that involves small arteries, veins, and capillaries throughout the body. The upper respiratory tract, lower respiratory tract, and kidney are most commonly affected. Clinically, glucocorticoid combined with cyclophosphamide is the first treatment for GPA. Herein, we report a case of refractory GPA. Combined with the literature review, we found that interleukin-6 (IL-6) levels were generally elevated in GPA patients. IL-6 is involved in the pathogenesis of antineutrophil cytoplasmic antibody-related small vessel vasculitis. We successfully treated a patient with refractory GPA using the IL-6 inhibitor-tocilizumab. Tocilizumab is an option when conventional immunosuppressants and rituximab are not effective in treating GPA. |
| Publish Date |
2023-02-14 07:03 |
| Citation |
Tang PF, Xu LC, Hong WT, Shi HY. Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids: A case report. World J Clin Cases 2023; 11(5): 1144-1151 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i5/1144.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i5.1144 |
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