Publication Name	World Journal of Gastroenterology
Manuscript ID	8140
Country	United States

Received	2013-12-18 10:04
Peer-Review Started	2013-12-18 16:19
To Make the First Decision	2014-01-09 19:15
Return for Revision	2014-02-14 08:45
Revised	2014-03-07 00:45
Second Decision	2014-04-16 11:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 12:04
Articles in Press	2014-05-23 09:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-13 19:39
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases
Manuscript Source	Invited Manuscript
All Author List	Jessica A Williams, Sharon Manley and Wen-Xing Ding
Funding Agency and Grant Number	Funding Agency Grant Number NIAAA funds R01 AA020518 National Center for Research Resources 5P20RR021940 National Center for Research Resources T32 ES007079 Biomedical Research Training Program Fellowship from University of Kansas Medical Center
Corresponding Author	Wen-Xing Ding, PhD, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018 3901 Rainbow Blvd., Kansas City, KS 66160, United States. wxding@kumc.edu
Key Words	Alcoholic liver disease; Autophagy; Fatty liver; Lipin-1; FoxO3; RIP3; IL-22
Core Tip	Alcoholic liver disease is a major health problem worldwide. Significant progress has been made to understand key events and molecular players for the onset and progression of alcoholic liver disease. This review summarizes the recent progress on animal models used to study alcoholic liver disease and the detrimental factors that contribute to alcoholic liver disease pathogenesis including miRNAs, S-adenosylmethionine, zinc deficiency, cytosolic lipin-1?, IRF3-mediated apoptosis, RIP3-mediated necrosis and hepcidin. In addition, we summarize emerging adaptive protective effects induced by alcohol to attenuate alcohol-induced liver pathogenesis including FoxO3, IL-22, autophagy and nuclear lipin-1?.
Publish Date	2014-10-01 20:25
Citation	Williams JA, Manley S, Ding WX. New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol 2014; 20(36): 12908-12933
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/12908.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.12908

Full Article (PDF)	WJG-20-12908.pdf
Full Article (Word)	WJG-20-12908.doc
Manuscript File	8140-Review.docx
Answering Reviewers	8140-Answering reviewers.pdf
Copyright License Agreement	8140-Copyright assignment.pdf
Peer-review Report	8140-Peer review.pdf
Scientific Editor Work List	8140-Scientific editor work list.doc