Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	81468
Country	Russia

Received	2022-11-10 15:05
Peer-Review Started	2022-11-10 15:09
To Make the First Decision
Return for Revision	2022-12-14 02:54
Revised	2023-01-06 20:20
Second Decision	2023-02-20 03:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-02-22 22:43
Articles in Press	2023-02-22 22:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-02-28 03:04
Typeset the Manuscript	2023-03-07 04:54
Publish the Manuscript Online	2023-03-15 02:14

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Genetic heterogeneity of colorectal cancer and the microbiome
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova
ORCID	Author(s) ORCID Number Marina A Senchukova http://orcid.org/0000-0001-8371-740X
Funding Agency and Grant Number
Corresponding Author	Marina A Senchukova, MD, PhD, Professor, Oncology, Orenburg State Medical University, Sovetskaya street, 6, Orenburg 460000, Russia. masenchukova@yandex.com
Key Words	Gut microbiota; Bacterial metabolites; Colorectal cancer; Colorectal polyp; Stem cells; Epigenetic changes
Core Tip	Most cases of colorectal cancer (CRC) develop from colorectal polyps that can progress to intramucosal carcinoma and CRC. A large number of studies have indicated that the gut microbiota may play a key role in the initiation and progression of CRC. The mini-review discusses current ideas about the role of the microbiome and microbial metabolites in inflammation initiation, activation of proliferative activity in intestinal epithelial and stem cells and development of genetic and epigenetic changes in CRC. Further research in this direction is of great interest since these studies may contribute to the development of new CRC prevention and treatment methods.
Publish Date	2023-03-15 02:14
Citation	Senchukova MA. Genetic heterogeneity of colorectal cancer and the microbiome. World J Gastrointest Oncol 2023;15(3): 443-463
URL	https://www.wjgnet.com/1948-5204/full/v15/i3/443.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i3.443

Full Article (PDF)	WJGO-15-443.pdf
Full Article (Word)	WJGO-15-443.docx
Manuscript File	81468-Review-FilipodiaCL.docx
Answering Reviewers	81468-Answering reviewers.pdf
Audio Core Tip	81468-Audio core tip.aac
Conflict-of-Interest Disclosure Form	81468-Conflict-of-interest statement.pdf
Copyright License Agreement	81468-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81468-Language certificate.pdf
Peer-review Report	81468-Peer-review(s).pdf
Scientific Misconduct Check	81468-Bing-Liu GL-2.png
Scientific Editor Work List	81468-Scientific editor work list.pdf
CrossCheck Report	81468-CrossCheck report.pdf