Publication Name	World Journal of Clinical Cases
Manuscript ID	81492
Country	China

Received	2022-11-16 10:27
Peer-Review Started	2022-11-16 10:29
To Make the First Decision
Return for Revision	2022-11-25 02:45
Revised	2022-12-11 16:09
Second Decision	2023-01-09 03:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-01-09 09:41
Articles in Press	2023-01-09 09:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-01-10 08:30
Publish the Manuscript Online	2023-02-06 06:38

ISSN	2307-8960 (online)
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Category	Immunology
Manuscript Type	Case Report
Article Title	Development of Henoch-Schoenlein purpura in a child with idiopathic hypereosinophilia syndrome with multiple thrombotic onset: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Yan Xu, Xiao-Bi Huang, Yun-Gong Wang, Li-Yun Zheng, Min Li, Yu Dai and Sheng Zhao
ORCID	Author(s) ORCID Number Yan-Yan Xu http://orcid.org/0000-0001-9808-5927 Xiao-Bi Huang http://orcid.org/0000-0002-8827-6145 Sheng Zhao http://orcid.org/0000-0002-4116-8403
Funding Agency and Grant Number
Corresponding Author	Sheng Zhao, MMed, Chief Doctor, Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui Hospital of Children's Hospital Affiliated with Fudan University, No. 39 Wangjiang East Road, Hefei 230051, Anhui Province, China. 382877830@qq.com
Key Words	Eosinophil; Hypereosinophilic syndrome; Henoch-Schoenlein purpura; Thrombosis; Case report
Core Tip	Pulmonary embolism (PE) in children usually occurs in the presence of an underlying condition, systemic disease, or other risk factors. Idiopathic PE accounts for less than 4% of these. The child has no risk factors for thrombosis other than obesity at the first hospitalization. A month later, he developed a purpuric rash on both legs, and pain in his ankles consistent with Henoch-Schönlein purpura (HSP) was accompanied by severe eosinophilia and motor and sensory impairments. Persistent eosinophilia in peripheral blood can lead to tissue infiltration and even organ damage. If end-organ damage occurs, hypereosinophilic syndrome (HES) can be diagnosed immediately. According to monist principles, patients are diagnosed with idiopathic HES with multiple embolisms complicated by HSP. After glucocorticoids, eosinophils quickly return to normal, neurological symptoms gradually improve, and the rash disappears. Eosinophils are only mildly elevated in PE, making clinical diagnosis more difficult.
Publish Date	2023-02-06 06:38
Citation	Xu YY, Huang XB, Wang YG, Zheng LY, Li M, Dai Y, Zhao S. Development of Henoch-Schoenlein purpura in a child with idiopathic hypereosinophilia syndrome with multiple thrombotic onset: A case report. World J Clin Cases 2023; 11(4): 952-961
URL	https://www.wjgnet.com/2307-8960/full/v11/i4/952.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i4.952

Full Article (PDF)	WJCC-11-952.pdf
Full Article (Word)	WJCC-11-952.docx
CARE Checklist–2016	81492-CARE-Checklist–2016-revision.pdf
Manuscript File	81492_Auto_Edited-jlw.docx
Answering Reviewers	81492-Answering reviewers.pdf
Audio Core Tip	81492-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	81492-Conflict-of-interest statement.pdf
Copyright License Agreement	81492-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	81492-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	81492-Language certificate.pdf
Peer-review Report	81492-Peer-review(s).pdf
Scientific Misconduct Check	81492-Bing-Chen YL-2.png
Scientific Editor Work List	81492-Scientific editor work list.pdf
CrossCheck Report	81492-CrossCheck report.pdf