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Articles Published Processes
2/24/2023 1:35:50 PM | Browse: 293 | Download: 823
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Received |
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2022-11-22 22:02 |
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Peer-Review Started |
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2022-11-22 22:04 |
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To Make the First Decision |
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Return for Revision |
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2022-12-10 07:38 |
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Revised |
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2022-12-14 08:40 |
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Second Decision |
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2023-01-18 03:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-01-18 23:39 |
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Articles in Press |
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2023-01-18 23:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-01-19 09:11 |
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Publish the Manuscript Online |
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2023-02-24 13:35 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You-Wen Tan, Jia-Min Wang and Xing-Bei Zhou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Social Development Project of Jiangsu Province, China |
BE2020775 |
| Chinese Federation of Public Health foundation |
GWLM202002 |
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| Corresponding Author |
You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300, Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu Province, China. tyw915@sina.com |
| Key Words |
Nonalcoholic fatty liver disease; Steatohepatitis; Chronic hepatitis B virus infection; Hepatocellular carcinoma; Cirrhosis |
| Core Tip |
A total of 456 patients with chronic hepatitis B virus infection were included in the study, of whom 152 (33.3%) had histologically confirmed nonalcoholic fatty liver disease (NAFLD). The median follow-up time of the entire cohort was 70.5 mo. Kaplan-Meier (K-M) survival analysis showed that NAFLD was not significantly associated with the risk of cirrhosis. Patients with chronic hepatitis B with fibrosis at baseline were more prone to cirrhosis. After PSM, multivariate analysis showed that diabetes mellitus, ballooning deformation, and platelet were independent risk factors for cirrhosis. A total of 10 patients (2.2%) developed hepatocellular carcinoma (HCC). K-M survival analysis showed that the cumulative risk of HCC in the NAFLD group was significantly higher. Cox multivariate analysis revealed that hepatocyte ballooning, liver fibrosis, and diabetes mellitus were independent risk factors for HCC. |
| Publish Date |
2023-02-24 13:35 |
| Citation |
Tan YW, Wang JM, Zhou XB. Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease. World J Hepatol 2023; 15(2): 237-254 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i2/237.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i2.237 |
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