Publication Name	World Journal of Gastroenterology
Manuscript ID	81978
Country	India

Received	2022-12-11 09:17
Peer-Review Started	2022-12-11 09:20
To Make the First Decision
Return for Revision	2023-01-11 05:31
Revised	2023-01-26 14:36
Second Decision	2023-04-07 01:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-07 03:34
Articles in Press	2023-04-07 03:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-30 20:03
Typeset the Manuscript	2023-04-17 05:53
Publish the Manuscript Online	2023-04-24 11:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Ferroptosis regulates key signaling pathways in gastrointestinal tumors: Underlying mechanisms and therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Ravichandiran Rabitha, Sethuraman Shivani, Yahya Showket and Ganapasam Sudhandiran
ORCID	Author(s) ORCID Number Yahya Showket http://orcid.org/0000-0001-6509-7032 Ganapasam Sudhandiran http://orcid.org/0000-0003-0066-7801
Funding Agency and Grant Number
Corresponding Author	Ganapasam Sudhandiran, MPhil, PhD, Full Professor, Department of Biochemistry, University of Madras, Cell Biology Research Laboratory, Gandhi Mandapam Road, Chennai 600025, Tamil Nadu, India. sudhandiran@unom.ac.in
Key Words	Ferroptosis; Gastrointestinal cancers; Nuclear factor erythroid 2–related factor 2; Apoptosis; Autophagy
Core Tip	Gastrointestinal tumors contribute to the majority of cancer-related deaths. Ferroptosis is a novel form of non-apoptotic cell death that plays a vital role in reducing the invasiveness and metastasis of gastrointestinal tumors. Herein, we discussed the regulatory mechanisms involved in ferroptosis through the hallmark pathways of glutathione peroxidase 4, iron metabolism, lipid peroxidation, and redox signaling that provide a novel therapeutic approach for gastrointestinal cancers.
Publish Date	2023-04-24 11:14
Citation	Rabitha R, Shivani S, Showket Y, Sudhandiran G. Ferroptosis regulates key signaling pathways in gastrointestinal tumors: Underlying mechanisms and therapeutic strategies. World J Gastroenterol 2023; 29(16): 2433-2451
URL	https://www.wjgnet.com/1007-9327/full/v29/i16/2433.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i16.2433

Full Article (PDF)	WJG-29-2433.pdf
Full Article (Word)	WJG-29-2433.docx
Manuscript File	81978_Auto_Edited-LiL-FilipodiaCL-JLW.docx
Answering Reviewers	81978-Answering reviewers.pdf
Audio Core Tip	81978-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81978-Conflict-of-interest statement.pdf
Copyright License Agreement	81978-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81978-Language certificate.pdf
Peer-review Report	81978-Peer-review(s).pdf
Scientific Misconduct Check	81978-Bing-Li L-2.png
Scientific Editor Work List	81978-Scientific editor work list.pdf
CrossCheck Report	81978-CrossCheck report.pdf
CrossCheck Report	81978-CrossCheck.png