| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Xing Hu, Zhuo Liu, Zhen Zhang, Zhe Deng, Zhen Huang, Ting Feng, Qing-Hong Zhou, Si Mei, Chun Yi, Qing Zhou, Pu-Hua Zeng, Gang Pei, Sha Tian and Xue-Fei Tian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (Key Program) |
U20A20408 |
| National Natural Science Foundation of China (General Program) |
82074450 |
| Natural Science Foundation of Hunan Province |
2020JJ4066 |
| Natural Science Foundation of Hunan Province |
2021JJ40405 |
| Key scientific research project of Hunan Education Department |
21A0243 |
| Key project of academician workstation guidance project |
21YS003 |
|
| Corresponding Author |
Xue-Fei Tian, PhD, Professor, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha 410208, Hunan Province, China. 003640@hnucm.edu.cn |
| Key Words |
Scolopendra; Centipede; Antihepatom peptide; Hepatocellular carcinoma; Death receptor 4; Death receptor 5 |
| Core Tip |
Centipedes have been used to treat tumors for hundreds of years in China. However, the molecular identities of their bioactive components have not yet been extensively investigated. We have modified the centipede extraction method and found a polypeptide (scolopentide) with the strongest antihepatoma activity. Mechanistically, scolopentide activated death receptor 4 and death receptor 5 to induce apoptosis through a mitochondria-independent pathway. Scolopentide may be an inspiration for the development of antihepatoma agents. We also aim to provide a reference for the purification and characterization of effective components in animal-derived medicines. |
| Publish Date |
2023-03-28 12:59 |
| Citation |
Hu YX, Liu Z, Zhang Z, Deng Z, Huang Z, Feng T, Zhou QH, Mei S, Yi C, Zhou Q, Zeng PH, Pei G, Tian S, Tian XF. Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans. World J Gastroenterol 2023; 29(12): 1875-1898 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i12/1875.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i12.1875 |
