| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Dong Zhao, Min Sun, Yan Li, Chan-Juan Yu, Ruo-Dong Cheng, Si-Hai Wang, Xue Du and Zhao-Hui Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University Scientific Research Projects of Anhui |
KJ2020A0401 |
| University Scientific Research Projects of Anhui |
2022AH050491 |
| Ministry of Education Key Laboratory of Glucolipid Metabolic Disorder |
GYDKFXM01 |
| Anhui University Collaborative Innovation Project |
GXXT-2020-025 |
| National Natural Science Foundation of China |
82174153 |
| National Key Research and Development Program |
2018YFC1704202 |
| Anhui Provincial Quality Engineering Project of Universities |
2021jyxm0834 |
| Major and Difficult Diseases Project of Anhui Province |
2021zdynjb06 |
| Clinical Research Project of Anhui University of Traditional Chinese Medicine |
2021yfylc01 |
|
| Corresponding Author |
Zhao-Hui Fang, PhD, Chief Doctor, Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei 230031, Anhui Province, China. fangzhaohui1111@163.com |
| Key Words |
Type 2 diabetes mellitus; Gut microbial; Metabolites; Goto-Kakizaki rats; Metagenomic; Untargeted metabolomic |
| Core Tip |
Studies suggested that the gut microbial and metabolites has an essential role in Goto Kakizaki rats. The results revealed evidence of a decrease in Prevotella sp. CAG:604 and Lactobacillus_murinus. Allobaculum_stercoricanis is increase. Fourteen potential metabolism biomarkers were glycochenodeoxycholic acid, uric acid, N-acetylaspartate, β-sitostenone, sphinganine, 4-pyridoxic acid, 13(S)-hydroxyoctadecadienoic acid, linoleic acid, etc. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
Zhao JD, Sun M, li Y, Yu CJ, Cheng RD, Wang SH, Du X, Fang ZH. Characterization of gut microbial and metabolite alterations in faeces of Goto Kakizaki rats using metagenomic and untargeted metabolomic approach. World J Diabetes 2023; 14(3): 255-270 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/255.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.255 |
