Publication Name	World Journal of Gastroenterology
Manuscript ID	82159
Country	China

Received	2022-12-07 07:56
Peer-Review Started	2022-12-07 07:58
To Make the First Decision
Return for Revision	2023-01-22 22:43
Revised	2023-02-10 16:02
Second Decision	2023-04-04 03:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-04 08:35
Articles in Press	2023-04-04 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-04-13 22:16
Typeset the Manuscript	2023-04-23 06:30
Publish the Manuscript Online	2023-05-07 07:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Letter to the Editor
Article Title	T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Yang, Qiao-Qi Li, Yong-Mei Liu and Biao Yang
ORCID	Author(s) ORCID Number Yong-Mei Liu http://orcid.org/0000-0002-0346-1158 Biao Yang http://orcid.org/0000-0003-2150-8690
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82200695
Corresponding Author	Biao Yang, MD, PhD, Professor, Surgeon, Teacher, Department of Abdominal Oncology, Division of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. landayb@163.com
Key Words	Immunosuppression; Pancreatic cancer stroma; T cell; Ttryptophan metabolism
Core Tip	There are numerous evidences for tryptophan metabolism served as an immunomodulatory factor. The indoleamine2,3-dioxygenase1 (IDO1) overexpression inhibits the maturation of dendritic cells and T-cell proliferation in spleen. Highly expression of kynurenine induces and activates aryl hydrocarbon receptor results in upregulates programmed cell death protein 1 expression. The induction of IDO1 can lead to the loss of Th17/Treg balance. We also found that overexpression of IDO1 upregulates the CD8+ T cells and reduce natural killer T cells in PC in mice.
Publish Date	2023-05-07 07:47
Citation	Yang T, Li QQ, Liu YM, Yang B. T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation. World J Gastroenterol 2023; 29(17): 2701-2703
URL	https://www.wjgnet.com/1007-9327/full/v29/i17/2701.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i17.2701

Full Article (PDF)	WJG-29-2701.pdf
Full Article (Word)	WJG-29-2701.docx
Manuscript File	82159-Review-FilipodiaCL.docx
Answering Reviewers	82159-Answering reviewers.pdf
Audio Core Tip	82159-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	82159-Conflict-of-interest statement.pdf
Copyright License Agreement	82159-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82159-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82159-Language certificate.pdf
Peer-review Report	82159-Peer-review(s).pdf
Scientific Misconduct Check	82159-Bing-Liu GL-2.png
Scientific Editor Work List	82159-Scientific editor work list.pdf
CrossCheck Report	82159-CrossCheck report.pdf