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Articles Published Processes
3/23/2023 8:29:43 AM | Browse: 245 | Download: 625
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Received |
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2022-12-16 07:22 |
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Peer-Review Started |
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2022-12-16 07:25 |
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To Make the First Decision |
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Return for Revision |
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2023-02-03 18:21 |
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Revised |
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2023-02-10 08:18 |
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Second Decision |
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2023-03-08 03:07 |
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Accepted by Journal Editor-in-Chief |
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2023-03-09 05:45 |
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Accepted by Executive Editor-in-Chief |
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2023-03-17 05:46 |
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Articles in Press |
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2023-03-17 05:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-20 01:53 |
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Publish the Manuscript Online |
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2023-03-23 08:29 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shuichiro Higo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| JSPS KAKENHI |
20K21602 |
| JSPS KAKENHI |
21H02915 |
| JSPS KAKENHI |
22K19526 |
| the Japan Agency for Medical Research and Development |
21bm0804008h0005 |
| the Cell Science Research Foundation |
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| the Grant for Basic Research of the Japanese Circulation Society (2018) |
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| SENSHIN Medical Research Foundation |
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| Corresponding Author |
Shuichiro Higo, MD, PhD, Associate Professor, Department of Medical Therapeutics for Heart Failure, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. higo-s@cardiology.med.osaka-u.ac.jp |
| Key Words |
Cardiomyopathy; Advanced heart failure; Induced pluripotent stem cell-derived cardiomyocytes; Desmosome; Genome editing; Gene therapy |
| Core Tip |
Prevention of advanced heart failure caused by cardiomyopathy is an urgent unmet need in the field of cardiovascular medicine. Desmosome, a cell-to-cell junctional component, maintains the structural integrity of heart tissues. Genetic mutations in desmosomal genes cause desmosome-related cardiomyopathy, an intractable disease refractory to standard medical therapies. This review introduces the recent advances in disease modeling of desmosome-related cardiomyopathy caused by PKP2 mutations using induced pluripotent stem cell-derived cardiomyocytes. |
| Publish Date |
2023-03-23 08:29 |
| Citation |
Higo S. Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes. World J Stem Cells 2023; 15(3): 71-82 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i3/71.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i3.71 |
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